The moment-to-moment processing of information by the nervous system involves the
propagation and interaction of electrical and chemical signals that are distributed in space …

The ageing of the human brain is a cause of cognitive decline in the elderly and the major
risk factor for Alzheimer's disease. The time in life when brain ageing begins is undefined …

Information processing is energetically expensive. In the mammalian brain, it is unclear how
information coding and energy use are regulated during food scarcity. Using whole-cell …

Shortly after John Eccles completed his studies of synaptic inhibition in the spinal cord, for
which he was awarded the 1963 Nobel Prize in physiology/medicine, he opened another …

Acquisition, analysis and simulation of electrophysiological properties of the nervous system
require multiple software packages. This makes it difficult to conserve experimental …

Markov kinetic models were used to synthesize a complete description of synaptic
transmission, including opening of voltage-dependent channels in the presynaptic terminal …

Synaptic plasticity is a key mechanism for chronic pain. It occurs at different levels of the
central nervous system, including spinal cord and cortex. Studies have mainly focused on …

A fragile balance between excitation and inhibition maintains the normal functioning of the
CNS. The dominant inhibitory neurotransmitter of the mammalian brain is GABA, which acts …

1. Excitatory postsynaptic currents (EPSCs) were recorded in CA3 pyramidal cells of
hippocampal slices of 15‐to 24‐day‐old rats (22 degrees C) using the whole‐cell …

Autism spectrum disorders (ASDs) comprise a heterogeneous group of pathological
conditions, mainly of genetic origin, characterized by stereotyped behavior, marked …