Klebsiella species cause a wide range of diseases including pneumonia, urinary tract
infections (UTIs), bloodstream infections and sepsis. These infections are particularly a …

STAT proteins represent an important family of evolutionarily conserved transcription factors
that play key roles in diverse biological processes, notably including blood and immune cell …

During the past two decades, interleukin-12 (IL-12) has emerged as one of the most potent
cytokines in mediating antitumor activity in a variety of preclinical models. Through …

Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …

A novel sequence discovered in a computational screen appears distantly related to the p35
subunit of IL-12. This factor, which we term p19, shows no biological activity by itself; …

CD4 T cells potentiate the inflammatory or humoral immune response through the action of
Th1 and Th2 cells, respectively. The molecular basis of the differentiation of these cells from …

The Janus family kinases (Jaks), Jak1, Jak2, Jak3, and Tyk2, form one subgroup of the non‐
receptor protein tyrosine kinases. They are involved in cell growth, survival, development …

▪ Abstract Natural killer (NK) cells are populations of lymphocytes that can be activated to
mediate significant levels of cytotoxic activity and produce high levels of certain cytokines …

IL-23 is a heterodimeric cytokine composed of the IL-12p40 “soluble receptor” subunit and a
novel cytokine-like subunit related to IL-12p35, termed p19. Human and mouse IL-23 exhibit …

Abstract T helper type 1 (Th1) lymphocytes secrete secrete interleukin (IL)-2, interferon-γ,
and lymphotoxin-α and stimulate type 1 immunity, which is characterized by intense …