Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …

Drug repositioning is the process of identifying novel therapeutic potentials for existing drugs
and discovering therapies for untreated diseases. Drug repositioning, therefore, plays an …

Plenty of microRNAs (miRNAs) were discovered at a rapid pace in plants, green algae,
viruses and animals. As one of the most important components in the cell, miRNAs play a …

Computational drug repositioning or repurposing is a promising and efficient tool for
discovering new uses from existing drugs and holds the great potential for precision …

Large-scale perturbation databases, such as Connectivity Map (CMap) or Library of
Integrated Network-based Cellular Signatures (LINCS), provide enormous opportunities for …

Small molecule is a kind of low molecular weight organic compound with variety of
biological functions. Studies have indicated that small molecules can inhibit a specific …

We provide an overview of recent developments in big data analyses in the context of
precision medicine and health informatics. With the advance in technologies capturing …

Mounting evidence has demonstrated the significance of taking microRNAs (miRNAs) as the
target of small molecule (SM) drugs for disease treatment. Given the fact that exploring new …

MicroRNAs (miRNAs) play crucial roles in human disease and can be targeted by small
molecule (SM) drugs according to numerous studies, which shows that identifying SM …

Aberrant expression of miRNAs is critically implicated in cancer initiation and progression.
Therapeutic approaches focused on regulating miRNAs are therefore a promising approach …