Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

We present HepatoNet1, the first reconstruction of a comprehensive metabolic network of
the human hepatocyte that is shown to accomplish a large canon of known metabolic liver …

The chemical identification of mass spectrometric signals in metabolomic applications is
important to provide conversion of analytical data to biological knowledge about metabolic …

Polypharmacology has emerged as novel means in drug discovery for improving treatment
response in clinical use. However, to really capitalize on the polypharmacological effects of …

Pathogens manipulate the cellular mechanisms of host organisms via pathogen–host
interactions (PHIs) in order to take advantage of the capabilities of host cells, leading to …

Cancer is a complex disease that involves multiple types of biological interactions across
diverse physical, temporal, and biological scales. This complexity presents substantial …

Mardinoglu A, Nielsen J (University of Technology, Gothenburg, Sweden). Systems
medicine and metabolic modelling (Key Symposium). J Intern Med 2012; 271: 142–154 …

Cellular metabolism continuously processes an enormous range of external compounds into
endogenous metabolites and is as such a key element in human physiology. The …

Polypharmacology provides a new way to address the issue of high attrition rates arising
from lack of efficacy and toxicity. However, the development of polypharmacology is …