Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …

Functional neural competence and integrity require interactive exchanges among sensory
and motor neurons, interneurons and glial cells. Recent studies have attributed some of the …

The WNT signal transduction cascade controls myriad biological phenomena throughout
development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a …

Wnt signalling has important roles during development and in many diseases. As
morphogens, hydrophobic Wnt proteins exert their function over a distance to induce …

Signaling by the Wnt family of secreted glycolipoproteins via the transcriptional coactivator β-
catenin controls embryonic development and adult homeostasis. Here we review recent …

The endosomal network comprises an interconnected network of membranous
compartments whose primary function is to receive, dissociate, and sort cargo that originates …

The retromer complex is a vital element of the endosomal protein sorting machinery that is
conserved across all eukaryotes. Retromer is most closely associated with the endosome-to …

Wnt proteins comprise a major family of signaling molecules that orchestrate and influence a
myriad of cell biological and developmental processes. Although our understanding of the …

Endocytic sorting of signalling receptors between recycling and degradative pathways is a
key cellular process controlling the surface complement of receptors and, accordingly, the …

In many contexts, self-renewal and differentiation of stem cells are influenced by signals
from their environment, constituting a niche. It is postulated that stem cells compete for local …