Glutamate is the primary excitatory neurotransmitter of the brain. Cellular homeostasis of
glutamate is of paramount importance for normal brain function and relies on an intricate …

Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …

Glutamate is the major excitatory neurotransmitter in the central nervous system. Glutamate
transmission efficiency depends on the correct functionality and expression of a plethora of …

The tryptophan and kynurenine pathway is well-known to play an important role in nervous,
endocrine, and immune systems, as well as in the development of inflammatory diseases. It …

Dysregulation of glutamatergic neural circuits has been implicated in a cycle of toxicity,
believed among the neurobiological underpinning of Alzheimer's disease. Previously, we …

A key hallmark of Alzheimer's disease (AD) pathology is the intracellular accumulation of tau
protein in the form of neurofibrillary tangles across large-scale networks of the human brain …

Understanding the role of astrocytes in the central nervous system has changed dramatically
over the last decade. The accumulating findings indicate that glial cells are involved not only …

The imbalance between glutamate and γ‐aminobutyric acid (GABA) results in the loss of
synaptic strength leading to neurodegeneration. The dogma on the field considered neurons …

The excitatory amino acid transporter 2 (EAAT2) plays a key role in the clearance and
recycling of glutamate-the major excitatory neurotransmitter in the mammalian brain. EAAT2 …

At mammalian neuronal synapses, synaptic vesicle (SV) glycoproteins are essential for
robust neurotransmission. Asparagine (N)-linked glycosylation is required for delivery of the …