Cellular senescence, a permanent state of cell cycle arrest accompanied by a complex
phenotype, is an essential mechanism that limits tumorigenesis and tissue damage. In …

The evolutionarily conserved Forkhead box O (FOXO) family of transcription factors
regulates multiple transcriptional targets involved in various cellular processes, including …

Mutations of NPHS1 or NPHS2, the genes encoding nephrin and podocin, as well as the
targeted disruption of CD2-associated protein (CD2AP), lead to heavy proteinuria …

Human cells in culture have a limited proliferative capacity. After a period of vigorous
proliferation, the rate of cell division declines and a number of changes occur in the cells …

Diseases of the glomerular filter of the kidney are a leading cause of end-stage renal failure.
Recent studies have emphasized the critical role of the slit diaphragm of podocytes for the …

Diabetes refers to a group of metabolic diseases characterized by impaired insulin
signalling and high blood glucose. A growing body of epidemiological evidence links …

The lifetime exposure of organisms to oxidative stress influences many aging processes
which involve the turnover of the extracellular matrix. In this study, we identify the redox …

Molecular changes associated with cellular senescence in human diploid fibroblasts (HDF),
IMR-90, were analyzed by two-dimensional differential proteome analysis. A high …

The proteasome constitutes the main non‐lysosomal cellular protease activity, and plays a
crucial role not only in the disposal of unwanted material, but also in the regulation of …

The retained placenta is a common pathology of dairy cows. It is associated with a
significant drop in the dry matter intake, milk yield, and increased susceptibility of dairy cows …