Liver allograft rejection remains a significant cause of morbidity and graft failure in liver
transplant recipients. Rejection is caused by the recognition of non-self donor alloantigens …

The central goal of regenerative medicine is to replace damaged or diseased tissue with
cells that integrate and function optimally. The capacity of pluripotent stem cells to produce …

Objective To assess whether reshaping of the immune balance by infusion of autologous
natural regulatory T cells (nTregs) in patients after kidney transplantation is safe, feasible …

Regulatory T cell (Treg) therapy using recipient-derived Tregs expanded ex vivo is currently
being investigated clinically by us and others as a means of reducing allograft rejection …

Type 1 regulatory T (Tr1) cells are inducible, interleukin (IL)-10+ FOXP3− regulatory T cells
that can suppress graft-versus-host disease (GvHD) after allogeneic hematopoietic stem cell …

Rheumatoid arthritis (RA) is an autoimmune disease that mainly affects the joints but also
leads to systemic inflammation. Auto-reactivity and dysregulation of self-tolerance are …

Improper activation of the immune system contributes to a variety of clinical conditions,
including autoimmune and allergic diseases as well as solid organ and bone marrow …

Since their discovery, CD4+ CD25hiFOXP3hi regulatory T cells (Tregs) have been firmly
established as a critical cell type for regulating immune homeostasis through a plethora of …

Regulatory T cells (Tregs) are critical mediators of immune homeostasis and hold significant
promise in the quest for transplantation tolerance. Progress has now reached a critical …

CAR (Chimeric Antigen Receptor) T-cell therapy has revolutionized the field of oncology in
recent years. This innovative shift in cancer treatment also provides the opportunity to …