When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging

MM Mihaylova, A Chaix, M Delibegovic, JJ Ramsey… - Cell metabolism, 2023 - cell.com
An epidemic of obesity has affected large portions of the world, increasing the risk of
developing many different age-associated diseases, including cancer, cardiovascular …

Protein appetite as an integrator in the obesity system: the protein leverage hypothesis

D Raubenheimer, SJ Simpson - … Transactions of the …, 2023 - royalsocietypublishing.org
Despite the large volume and extensive range of obesity research, there is substantial
disagreement on the causes and effective preventative strategies. We suggest the field will …

[HTML][HTML] Gut bacterial nutrient preferences quantified in vivo

X Zeng, X Xing, M Gupta, FC Keber, JG Lopez… - Cell, 2022 - cell.com
Great progress has been made in understanding gut microbiomes' products and their effects
on health and disease. Less attention, however, has been given to the inputs that gut …

[HTML][HTML] Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction

CL Green, HH Pak, NE Richardson, V Flores, D Yu… - Cell metabolism, 2022 - cell.com
Low-protein diets promote metabolic health in humans and rodents. Despite evidence that
sex and genetic background are key factors in the response to diet, most protein intake …

[HTML][HTML] Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota

H Li, L Zhang, J Li, Q Wu, L Qian, J He, Y Ni… - Nature …, 2024 - nature.com
Emerging evidence suggests that modulation of gut microbiota by dietary fibre may offer
solutions for metabolic disorders. In a randomized placebo-controlled crossover design trial …

Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice

CL Green, ME Trautman, K Chaiyakul, R Jain, YH Alam… - Cell Metabolism, 2023 - cell.com
Low-protein diets promote health and longevity in diverse species. Restriction of the
branched-chain amino acids (BCAAs) leucine, isoleucine, and valine recapitulates many of …

[HTML][HTML] Non-alcoholic fatty liver disease and diabetes mellitus as growing aetiologies of hepatocellular carcinoma

S Talamantes, M Lisjak, EH Gilglioni… - JHEP Reports, 2023 - Elsevier
Obesity-related complications such as non-alcoholic fatty liver disease (NAFLD) and type 2
diabetes (T2D) are well-established risk factors for the development of hepatocellular …

Amino acid transporters as modulators of glucose homeostasis

S Bröer - Trends in Endocrinology & Metabolism, 2022 - cell.com
Amino acids modulate glucose homeostasis. Cytosolic levels of amino acids are regulated
by amino acid transporters, modulating insulin release, protein synthesis, cell proliferation …

Relationship between carbohydrate intake (quantity, quality, and time eaten) and mortality (total, cardiovascular, and diabetes): assessment of 2003–2014 national …

W Hou, T Han, X Sun, Y Chen, J Xu, Y Wang… - Diabetes …, 2022 - Am Diabetes Assoc
OBJECTIVE In this study we investigated the association of the quantity, quality, and timing
of carbohydrate intake with all-cause, cardiovascular disease (CVD), and diabetes mortality …

[HTML][HTML] Whole-grain intake in the Mediterranean diet and a low protein to carbohydrates ratio can help to reduce mortality from cardiovascular disease, slow down the …

C Capurso - Nutrients, 2021 - mdpi.com
Increase in the aging population is a phenomenon all over the world. Maintaining good
functional ability, good mental health, and cognitive function in the absence of severe …