Abstract Positive-sense RNA ((+) RNA) viruses such as hepatitis C virus exploit host cells by
subverting host proteins, remodelling subcellular membranes, co-opting and modulating …

Covering: up to April 2014 The development of drugs with broad-spectrum antiviral activities
is a long pursued goal in drug discovery. It has been shown that blocking co-opted host …

RNA silencing is a fundamental, evolutionarily conserved mechanism that regulates gene
expression in eukaryotes. It also functions as a primary immune defense in microbes, such …

Hepatitis C virus (HCV) replication is dependent on microRNA 122 (miR-122), a liver-
specific microRNA that recruits Argonaute 2 to the 5′ end of the viral genome, stabilizing it …

ABSTRACT miR-122 is a liver-specific microRNA that positively regulates hepatitis C virus
(HCV) RNA abundance and is essential for production of infectious HCV. Using a genetic …

We have developed genetically modified Ae. aegypti mosquitoes that activate the conserved
antiviral JAK/STAT pathway in the fat body tissue, by overexpressing either the receptor …

RNA granules are structures within cells that impart key regulatory measures on gene
expression. Two general types of RNA granules are conserved from yeast to mammals …

Dengue virus (DENV) is a rapidly re-emerging flavivirus that causes dengue fever (DF),
dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), diseases for which …

The microRNA miR-122 and DDX6/Rck/p54, a microRNA effector, have been implicated in
hepatitis C virus (HCV) replication. In this study, we demonstrated for the first time that HCV …

Zika virus (ZIKV) has been associated with microcephaly and other brain abnormalities;
however, the molecular consequences of ZIKV to human brain development are still not fully …