A determinant of axon regeneration is the intrinsic growth ability of injured neurons, which
dictates a battery of injury responses in axons and cell bodies. While some of these …

Failure of axon regeneration after central nervous system (CNS) injuries results in
permanent functional deficits. Numerous studies in the past suggested that blocking …

Axon regeneration in the adult CNS is prevented by inhibitors in myelin. These inhibitors
seem to modulate RhoA activity by binding to a receptor complex comprising a ligand …

Postinjury recovery in most tissues requires an effective dialog with macrophages; however,
in the mammalian central nervous system, this dialog may be restricted (possibly due to its …

The regenerative capacity of injured adult mammalian central nervous system (CNS) tissue
is very limited. Disease or injury that causes destruction or damage to neuronal networks …

Enabling axon regeneration after central nervous system (CNS) injury remains a major
challenge in neurobiology. One of the major differences between the injured peripheral …

Electrical and/or electromechanical stimulation has been shown to play a significant role in
regenerating various functionalities in soft tissues, such as tendons, muscles, and nerves. In …

By screening specific populations of rat brain cells, we found that ameboid microglia secrete
an 18 kD peptide with IL-1 biological activity. The IL-1 activity released by microglia was …

ARVIN, B., LF NEVILLE, FC BARONE AND GA FEUERSTEIN The role of inflammation and
cytokines in brain injury. NEUROSCI BIOBEHAV REV 20 (3) 445–452, 1996.—The original …

Interleukin-1 (IL-1), a protein produced by mononuclear phagocytes, helps to initiate the
inflammatory response through its action upon a diverse population of cells. Recently this …