Actin polymerization often occurs at the plasma membrane to drive the protrusion of
lamellipodia and filopodia at the leading edge of migrating cells. A role for actin …

Gene electrotransfer is a powerful method of DNA delivery offering several medical
applications, among the most promising of which are DNA vaccination and gene therapy for …

Coated pits assemble by growth of a clathrin lattice, which is linked by adaptors to the
underlying membrane. How does this process start? We used live-cell TIRF imaging with …

The extensive links between proteotoxic stress, protein aggregation and pathologies
ranging from ageing to neurodegeneration underscore the importance of understanding …

Endocytosis, like many dynamic cellular processes, requires precise temporal and spatial
orchestration of complex protein machinery to mediate membrane budding. To understand …

The endomembrane system consists of the secretory and endocytic pathways, which
communicate by transport to and from the trans-Golgi network (TGN). In mammalian cells …

Clathrin-mediated endocytosis in the budding yeast Saccharomyces cerevisiae involves the
ordered recruitment, activity and disassembly of nearly 60 proteins at distinct sites on the …

Stationary phase (stat-phase) is a poorly understood physiological state under which cells
arrest proliferation and acquire resistance to multiple stresses. Lipid droplets (LDs) …

In plants, clathrin mediated endocytosis (CME) represents the major route for cargo
internalisation from the cell surface. It has been assumed to operate in an evolutionary …

Mutations in the inositol 5-phosphatase OCRL are responsible for Lowe syndrome, whose
manifestations include mental retardation and renal Fanconi syndrome. OCRL has been …