Wide-ranging cellular functions of ion channels and lipid scramblases in the structurally related TMC, TMEM16 and TMEM63 families
LY Jan, YN Jan - Nature Structural & Molecular Biology, 2024 - nature.com
Abstract Calcium (Ca2+)-activated ion channels and lipid scramblases in the
transmembrane protein 16 (TMEM16) family are structurally related to mechanosensitive ion …
transmembrane protein 16 (TMEM16) family are structurally related to mechanosensitive ion …
In or out of the groove? Mechanisms of lipid scrambling by TMEM16 proteins
Phospholipid scramblases mediate the rapid movement of lipids between membrane
leaflets, a key step in establishing and maintaining membrane homeostasis of the …
leaflets, a key step in establishing and maintaining membrane homeostasis of the …
[HTML][HTML] Robust lipid scrambling by TMEM16 proteins requires an open groove and thin membrane
CA Stephens, N van Hilten, L Zheng, M Grabe - bioRxiv, 2024 - pmc.ncbi.nlm.nih.gov
Biological membranes are complex and dynamic structures with different populations of
lipids on their inner and outer leaflets. The Ca2+-activated TMEM16 family of membrane …
lipids on their inner and outer leaflets. The Ca2+-activated TMEM16 family of membrane …
Simulation-based survey of TMEM16 family reveals that robust lipid scrambling requires an open groove
CA Stephens, N van Hilten, L Zheng, M Grabe - bioRxiv, 2024 - biorxiv.org
Biological membranes are complex and dynamic structures with different populations of
lipids in their inner and outer leaflets. The Ca2+-activated TMEM16 family of membrane …
lipids in their inner and outer leaflets. The Ca2+-activated TMEM16 family of membrane …
Getting into the groove! Investigating how lipids, ions and water interact with dynamic protein cavities using physics-based simulations
C Stephens - 2024 - search.proquest.com
Proteins, both membrane dwelling and soluble, have the remarkable ability to alter their
shapes when they interact with other molecules. My work has focused on the ability of one …
shapes when they interact with other molecules. My work has focused on the ability of one …