[HTML][HTML] Mixture risk assessment and human biomonitoring: Lessons learnt from HBM4EU

M Luijten, J Vlaanderen, A Kortenkamp… - International Journal of …, 2023 - Elsevier
Unintentional chemical mixtures that are present in the environment are of societal concern
as the (environmental) chemicals contained therein, either singly or in combination, may …

[HTML][HTML] Cumulative risk assessment of five phthalates in European children and adolescents

R Lange, N Vogel, P Schmidt, A Gerofke… - International Journal of …, 2022 - Elsevier
Abstract The European Human Biomonitoring Initiative (HBM4EU) assessed human
biomonitoring data on phthalates in children and adolescents, that were sampled between …

[HTML][HTML] Mixture risk assessment of complex real-life mixtures—the PANORAMIX project

BI Escher, M Lamoree, JP Antignac, M Scholze… - International journal of …, 2022 - mdpi.com
Humans are involuntarily exposed to hundreds of chemicals that either contaminate our
environment and food or are added intentionally to our daily products. These complex …

Frequency, morbidity and equity—the case for increased research on male fertility

S Kimmins, RA Anderson, CLR Barratt… - Nature Reviews …, 2024 - nature.com
Currently, most men with infertility cannot be given an aetiology, which reflects a lack of
knowledge around gamete production and how it is affected by genetics and the …

Exploring the occurrence of organic contaminants in human semen through an innovative LC-HRMS-based methodology suitable for target and nontarget analysis

E Sánchez-Resino, M Marquès… - … science & technology, 2023 - ACS Publications
Understanding the potential impact of organic contaminants on male fertility is crucial, yet
limited studies have examined these chemicals in semen, with most focusing on urine and …

Cumulative risk evaluation of phthalates under TSCA

D Payne-Sturges, S De Saram… - … Science & Technology, 2023 - ACS Publications
The US Environmental Protection Agency (EPA) is currently conducting separate Toxic
Substances Control Act (TSCA) risk evaluations for seven phthalates: dibutyl phthalate …

[HTML][HTML] Drivers of divergent assessments of bisphenol-A hazards to semen quality by various European agencies, regulators and scientists

A Kortenkamp, O Martin, E Iacovidou… - International Journal of …, 2024 - Elsevier
The downward revision of the bisphenol A (BPA) Health-based Guidance Value (HBGV) by
the European Food Safety Authority (EFSA) has led to disagreements with other regulatory …

[HTML][HTML] A case study of neurodevelopmental risks from combined exposures to lead, methyl-mercury, inorganic arsenic, polychlorinated biphenyls, polybrominated …

C Sprong, JD Te Biesebeek, M Chatterjee… - International journal of …, 2023 - Elsevier
We performed a mixture risk assessment (MRA) case study of dietary exposure to the food
contaminants lead, methylmercury, inorganic arsenic (iAs), fluoride, non-dioxin-like …

[HTML][HTML] Co-exposure to 55 endocrine-disrupting chemicals linking diminished sperm quality: Mixture effect, and the role of seminal plasma docosapentaenoic acid

C Gao, N Sun, J Xie, J Li, L Tao, L Guo, L Shi… - Environment …, 2024 - Elsevier
Isolated effects of single endocrine-disrupting chemicals (EDCs) on male reproductive
health have been studied extensively, but their mixture effect remains unelucidated …

[HTML][HTML] Complex chemical mixtures: Approaches for assessing adverse human health effects

E Mustafa, MJ Valente, AM Vinggaard - Current Opinion in Toxicology, 2023 - Elsevier
In this opinion, we provide a brief overview of three main approaches for assessing effects of
chemical mixtures on human health, such as experimental or theoretical component-based …