In-cell structural biology by NMR: the benefits of the atomic scale

FX Theillet - Chemical reviews, 2022 - ACS Publications
In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

Paramagnetic chemical probes for studying biological macromolecules

Q Miao, C Nitsche, H Orton, M Overhand… - Chemical …, 2022 - ACS Publications
Paramagnetic chemical probes have been used in electron paramagnetic resonance (EPR)
and nuclear magnetic resonance (NMR) spectroscopy for more than four decades. Recent …

Facing and overcoming sensitivity challenges in biomolecular NMR spectroscopy

JH Ardenkjaer‐Larsen, GS Boebinger… - Angewandte Chemie …, 2015 - Wiley Online Library
In the Spring of 2013, NMR spectroscopists convened at the Weizmann Institute in Israel to
brainstorm on approaches to improve the sensitivity of NMR experiments, particularly when …

Causes and consequences of increased glucose metabolism of cancers

RJ Gillies, I Robey, RA Gatenby - Journal of Nuclear Medicine, 2008 - Soc Nuclear Med
In this review we examine the mechanisms (causes) underlying the increased glucose
consumption observed in tumors within a teleological context (consequences). In other …

Protein NMR using paramagnetic ions

G Otting - Annual review of biophysics, 2010 - annualreviews.org
Paramagnetic metal ions offer outstanding opportunities for protein studies by nuclear
magnetic resonance (NMR) spectroscopy. The paramagnetic effects manifested in the NMR …

A set of BEST triple-resonance experiments for time-optimized protein resonance assignment

E Lescop, P Schanda, B Brutscher - Journal of magnetic resonance, 2007 - Elsevier
A series of sequential, intra-residue, and bi-directional BEST H–N–CA, H–N–CO, and H–N–
CB pulse sequences is presented that extends the BEST concept introduced recently for fast …

Ultrafast 2D NMR: an emerging tool in analytical spectroscopy

P Giraudeau, L Frydman - Annual Review of Analytical …, 2014 - annualreviews.org
Two-dimensional nuclear magnetic resonance (2D NMR) spectroscopy is widely used in
chemical and biochemical analyses. Multidimensional NMR is also witnessing increased …

Design of stable Ni/ZrO2 catalysts for dry reforming of methane

Y Lou, M Steib, Q Zhang, K Tiefenbacher, A Horváth… - Journal of catalysis, 2017 - Elsevier
ZrO 2 supported Ni with an average particle diameter of 1–2 nm were synthesized by
binding Ni 2+ in rccc-5, 11, 17, 23-tetrahydroxy-2, 8, 14, 20-tetra (n-decyl) resorcin [4] arene …

Protein folding and unfolding studied at atomic resolution by fast two-dimensional NMR spectroscopy

P Schanda, V Forge… - Proceedings of the …, 2007 - National Acad Sciences
Atom-resolved real-time studies of kinetic processes in proteins have been hampered in the
past by the lack of experimental techniques that yield sufficient temporal and atomic …

[HTML][HTML] Therapeutic potential of polypeptide-based conjugates: rational design and analytical tools that can boost clinical translation

T Melnyk, S Đorđević, I Conejos-Sanchez… - Advanced drug delivery …, 2020 - Elsevier
The clinical success of polypeptides as polymeric drugs, covered by the umbrella term
“polymer therapeutics,” combined with related scientific and technological breakthroughs …