Metabolism of activated T lymphocytes
JA Maciolek, JA Pasternak, HL Wilson - Current opinion in immunology, 2014 - Elsevier
Highlights•Effector T cells require increased glucose uptake/processing via aerobic
glycolysis.•Glutaminolysis is essential for activated effector T cell metabolism.•Activated …
glycolysis.•Glutaminolysis is essential for activated effector T cell metabolism.•Activated …
The immune control and cell-to-cell spread of human T-lymphotropic virus type 1
CRM Bangham - Journal of General Virology, 2003 - microbiologyresearch.org
Human T-lymphotropic virus type 1 (HTLV-1) varies little in sequence compared with human
immunodeficiency virus type 1 (HIV) and it is difficult to detect HTLV-1 mRNA, proteins or …
immunodeficiency virus type 1 (HIV) and it is difficult to detect HTLV-1 mRNA, proteins or …
Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
T cell activation requires that the cell meet increased energetic and biosynthetic demands.
We showed that exogenous nutrient availability regulated the differentiation of naïve CD4+ T …
We showed that exogenous nutrient availability regulated the differentiation of naïve CD4+ T …
[HTML][HTML] The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV
The human T cell leukemia virus (HTLV) is associated with leukemia and neurological
syndromes. The physiopathological effects of HTLV envelopes are unclear and the identity …
syndromes. The physiopathological effects of HTLV envelopes are unclear and the identity …
Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4+ T cells
KS Jones, C Petrow-Sadowski, YK Huang… - Nature medicine, 2008 - nature.com
Cell-free human T-lymphotropic virus type 1 (HTLV-1) virions are poorly infectious in vitro for
their primary target cells, CD4+ T cells. Here, we show that HTLV-1 can efficiently infect …
their primary target cells, CD4+ T cells. Here, we show that HTLV-1 can efficiently infect …
Erythrocyte Glut1 triggers dehydroascorbic acid uptake in mammals unable to synthesize vitamin C
Of all cells, human erythrocytes express the highest level of the Glut1 glucose transporter.
However, the regulation and function of Glut1 during erythropoiesis are not known. Here, we …
However, the regulation and function of Glut1 during erythropoiesis are not known. Here, we …
Increased glucose metabolic activity is associated with CD4+ T-cell activation and depletion during chronic HIV infection
Objectives: Glucose metabolism plays a fundamental role in supporting the growth,
proliferation and effector functions of T cells. We investigated the impact of HIV infection on …
proliferation and effector functions of T cells. We investigated the impact of HIV infection on …
Neuropilin-1 is involved in human T-cell lymphotropic virus type 1 entry
D Ghez, Y Lepelletier, S Lambert, JM Fourneau… - Journal of …, 2006 - Am Soc Microbiol
Human T-cell lymphotropic virus type 1 (HTLV-1) is transmitted through a viral synapse and
enters target cells via interaction with the glucose transporter GLUT1. Here, we show that …
enters target cells via interaction with the glucose transporter GLUT1. Here, we show that …
Entry of glucose-and glutamine-derived carbons into the citric acid cycle supports early steps of HIV-1 infection in CD4 T cells
The susceptibility of CD4 T cells to human immunodeficiency virus 1 (HIV-1) infection is
regulated by glucose and glutamine metabolism, but the relative contributions of these …
regulated by glucose and glutamine metabolism, but the relative contributions of these …
[HTML][HTML] Retroviral infection of non-dividing cells: old and new perspectives
M Yamashita, M Emerman - Virology, 2006 - Elsevier
The dependence of retroviral replication on cell proliferation was described as early as
1958, although different classes of retroviruses are able to infect non-dividing cells with …
1958, although different classes of retroviruses are able to infect non-dividing cells with …