SUMMARY HIV-1 DNA exists in nonintegrated linear and circular episomal forms and as
integrated proviruses. In patients with plasma viremia, most peripheral blood mononuclear …

Attempts to reduce the human immunodeficiency virus type 1 (HIV-1) reservoir and induce
antiretroviral therapy (ART)-free virologic control have largely been unsuccessful. In this …

Antiretroviral therapy controls HIV replication but does not eliminate the virus from the
infected host. The persistence of a small pool of cells harboring integrated and replication …

The decay kinetics of HIV-1-infected cells are critical to understand virus persistence. We
evaluated the frequency of simian immunodeficiency virus (SIV)-infected cells for 4 years of …

Within-host HIV populations continually diversify during untreated infection, and this diversity
persists within infected cell reservoirs during antiretroviral therapy (ART). Achieving a better …

Genetically-characterizing full-length HIV-1 RNA is critical for identifying genetically-intact
genomes and for comparing these RNA genomes to proviral DNA. We have developed a …

Dysregulation of the bone marrow niche resulting from the direct and indirect effects of HIV
infection contributes to haematological abnormalities observed in HIV patients. The bone …

During antiretroviral therapy (ART) that suppresses HIV replication to below the limit-of-
quantification, virions produced during ART can be detected at low frequencies in the …

A major barrier to human immunodeficiency virus (HIV-1) cure is the latent viral reservoir,
which persists despite antiretroviral therapy (ART), including across the non-dividing …

Human immunodeficiency virus 1 (HIV) proviruses archived in the persistent reservoir
currently pose the greatest obstacle to HIV cure due to their evasion of combined …