Hypertension affects a significant proportion of the adult and aging population and
represents an important risk factor for vascular cognitive impairment and late-life dementia …

Abstract Objective Vascular dementia (VaD) is the second most common cause of dementia
and a major health concern worldwide. A comprehensive review on VaD is warranted for …

Cerebral amyloid angiopathy, which is defined by cerebrovascular deposition of amyloid β,
is a common age-related small vessel pathology associated with intracerebral haemorrhage …

Dementia prevention research has progressed rapidly in recent years, with publication of
several large lifestyle intervention trials, and renewed interest in pharmacological …

Importance Meta-analyses of randomized clinical trials have indicated that improved
hypertension control reduces the risk for cognitive impairment and dementia. However, it is …

PURPOSE OF REVIEW This article gives a broad overview of vascular cognitive impairment
and dementia, including epidemiology, pathophysiology, clinical approach, and …

For decades, the hypothesis that brain deposition of the amyloid β protein initiates
Alzheimer's disease has dominated research and clinical trials. Targeting amyloid β is …

Background Obesity and related metabolic disturbances including diabetes, hypertension
and hyperlipidemia predict future cognitive decline. Asia has a high prevalence of both …

Cerebral small vessel disease (CSVD) is a generic term used for intracranial vascular
disorders caused by the structural changes of cerebral microvessels, including the small …

Cerebral small vessel disease (CSVD) has emerged as a common factor driving age-
dependent diseases, including stroke and dementia. CSVD-related dementia will affect a …