Engineering biomaterials that mimic the extracellular matrix (ECM) of bone is of significant
importance since most of the outstanding properties of the bone are due to matrix …

Osteopontin (OPN) is a highly phosphorylated sialoprotein that is a prominent component of
the mineralized extracellular matrices of bones and teeth. OPN is characterized by the …

The term 'matricellular'has been applied to a group of extracellular proteins that do not
contribute directly to the formation of structural elements in vertebrates but serve to modulate …

Living organisms are capable of inducing the crystallization and deposition of a wide variety
of minerals, 1 but the vertebrates mainly utilize the calcium phosphates in constructing their …

Cell-mediated (type-1) immunity is necessary for immune protection against most
intracellular pathogens and, when excessive, can mediate organ-specific autoimmune …

Some features of the OPN protein. Indicated sites of O-glycosylation and phosphorylation
are intended to be representative; both vary (phosphorylation in particular) with the source of …

Multiple sclerosis is a demyelinating disease, characterized by inflammation in the brain and
spinal cord, possibly due to autoimmunity. Large-scale sequencing of cDNA libraries …

Stem cells reside in a specialized niche that regulates their abundance and fate.
Components of the niche have generally been defined in terms of cells and signaling …

Osteopontin is a secreted glycoprotein with a multidomain structure and functions
characteristic of a matricellular protein. Osteopontin interacts with cell surface receptors via …

Osteopontin (OPN) is a multifunctional protein, and although highly expressed in bone, it is
also expressed by various cell types including macrophages, endothelial cells, smooth …