Evolution of the human pathogenic lifestyle in fungi

A Rokas - Nature Microbiology, 2022 - nature.com
Fungal pathogens cause more than a billion human infections every year, resulting in more
than 1.6 million deaths annually. Understanding the natural history and evolutionary ecology …

Fungal evolution: major ecological adaptations and evolutionary transitions

MA Naranjo‐Ortiz, T Gabaldón - Biological Reviews, 2019 - Wiley Online Library
Fungi are a highly diverse group of heterotrophic eukaryotes characterized by the absence
of phagotrophy and the presence of a chitinous cell wall. While unicellular fungi are far from …

Genomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species

JF Muñoz, L Gade, NA Chow, VN Loparev… - Nature …, 2018 - nature.com
Candida auris is an emergent multidrug-resistant fungal pathogen causing increasing
reports of outbreaks. While distantly related to C. albicans and C. glabrata, C. auris is closely …

Evolutionary Emergence of Drug Resistance in Candida Opportunistic Pathogens

E Ksiezopolska, T Gabaldón - Genes, 2018 - mdpi.com
Fungal infections, such as candidiasis caused by Candida, pose a problem of growing
medical concern. In developed countries, the incidence of Candida infections is increasing …

The quiet and underappreciated rise of drug-resistant invasive fungal pathogens

A Arastehfar, C Lass-Flörl, R Garcia-Rubio… - Journal of Fungi, 2020 - mdpi.com
Human fungal pathogens are attributable to a significant economic burden and mortality
worldwide. Antifungal treatments, although limited in number, play a pivotal role in …

Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells

M Pekmezovic, H Hovhannisyan, MS Gresnigt… - Nature …, 2021 - nature.com
Vaginal candidiasis is an extremely common disease predominantly caused by four
phylogenetically diverse species: Candida albicans; Candida glabrata; Candida …

Fungal evolution: cellular, genomic and metabolic complexity

MA Naranjo‐Ortiz, T Gabaldón - Biological Reviews, 2020 - Wiley Online Library
The question of how phenotypic and genomic complexity are inter‐related and how they are
shaped through evolution is a central question in biology that historically has been …

Importance of Resolving Fungal Nomenclature: the Case of Multiple Pathogenic Species in the Cryptococcus Genus

F Hagen, HT Lumbsch, V Arsic Arsenijevic, H Badali… - Msphere, 2017 - Am Soc Microbiol
Cryptococcosis is a major fungal disease caused by members of the Cryptococcus gattii and
Cryptococcus neoformans species complexes. After more than 15 years of molecular …

Recent trends in molecular diagnostics of yeast infections: from PCR to NGS

T Gabaldón - FEMS Microbiology Reviews, 2019 - academic.oup.com
The incidence of opportunistic yeast infections in humans has been increasing over recent
years. These infections are difficult to treat and diagnose, in part due to the large number …

Hybridization and the origin of new yeast lineages

T Gabaldón - FEMS Yeast Research, 2020 - academic.oup.com
Hybrids originate from the mating of two diverged organisms, resulting in novel lineages that
have chimeric genomes. Hybrids may exhibit unique phenotypic traits that are not …