[HTML][HTML] Biology and applications of CRISPR systems: harnessing nature's toolbox for genome engineering
Bacteria and archaea possess a range of defense mechanisms to combat plasmids and viral
infections. Unique among these are the CRISPR-Cas (clustered regularly interspaced short …
infections. Unique among these are the CRISPR-Cas (clustered regularly interspaced short …
Annotation and classification of CRISPR-Cas systems
KS Makarova, EV Koonin - CRISPR: methods and protocols, 2015 - Springer
The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas (CRISPR-
associated proteins) is a prokaryotic adaptive immune system that is represented in most …
associated proteins) is a prokaryotic adaptive immune system that is represented in most …
A programmable dual-RNA–guided DNA endonuclease in adaptive bacterial immunity
Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated
(Cas) systems provide bacteria and archaea with adaptive immunity against viruses and …
(Cas) systems provide bacteria and archaea with adaptive immunity against viruses and …
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49624232&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
49624232&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Unravelling the structural and mechanistic basis of CRISPR–Cas systems
Bacteria and archaea have evolved sophisticated adaptive immune systems, known as
CRISPR–Cas (clustered regularly interspaced short palindromic repeats–CRISPR …
CRISPR–Cas (clustered regularly interspaced short palindromic repeats–CRISPR …
RNA-guided genetic silencing systems in bacteria and archaea
Clustered regularly interspaced short palindromic repeat (CRISPR) are essential
components of nucleic-acid-based adaptive immune systems that are widespread in …
components of nucleic-acid-based adaptive immune systems that are widespread in …
CRISPR-mediated adaptive immune systems in bacteria and archaea
R Sorek, CM Lawrence… - Annual review of …, 2013 - annualreviews.org
Effective clearance of an infection requires that the immune system rapidly detects and
neutralizes invading parasites while strictly avoiding self-antigens that would result in …
neutralizes invading parasites while strictly avoiding self-antigens that would result in …
The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems
K Chylinski, A Le Rhun, E Charpentier - RNA biology, 2013 - Taylor & Francis
CRISPR-Cas is a rapidly evolving RNA-mediated adaptive immune system that protects
bacteria and archaea against mobile genetic elements. The system relies on the activity of …
bacteria and archaea against mobile genetic elements. The system relies on the activity of …
CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3
The prokaryotic CRISPR/Cas immune system is based on genomic loci that contain
incorporated sequence tags from viruses and plasmids. Using small guide RNA molecules …
incorporated sequence tags from viruses and plasmids. Using small guide RNA molecules …
Biogenesis pathways of RNA guides in archaeal and bacterial CRISPR-Cas adaptive immunity
E Charpentier, H Richter, J van der Oost… - FEMS microbiology …, 2015 - academic.oup.com
CRISPR-Cas is an RNA-mediated adaptive immune system that defends bacteria and
archaea against mobile genetic elements. Short mature CRISPR RNAs (crRNAs) are key …
archaea against mobile genetic elements. Short mature CRISPR RNAs (crRNAs) are key …