World Health Organization disability assessment schedule 2.0: An international systematic review

S Federici, M Bracalenti, F Meloni… - Disability and …, 2017 - Taylor & Francis
Purpose: This systematic review examines research and practical applications of the World
Health Organization Disability Assessment Schedule (WHODAS 2.0) as a basis for …

[HTML][HTML] New insights into the genetic etiology of Alzheimer's disease and related dementias

C Bellenguez, F Küçükali, IE Jansen, L Kleineidam… - Nature …, 2022 - nature.com
Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …

[HTML][HTML] Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture

Q Zhang, J Sidorenko, B Couvy-Duchesne… - Nature …, 2020 - nature.com
Genetic association studies have identified 44 common genome-wide significant risk loci for
late-onset Alzheimer's disease (LOAD). However, LOAD genetic architecture and prediction …

APOE genotype and MRI markers of cerebrovascular disease: Systematic review and meta-analysis

S Schilling, AL DeStefano, PS Sachdev, SH Choi… - Neurology, 2013 - AAN Enterprises
Objective: We aimed to examine the association of APOE ε genotype with MRI markers of
cerebrovascular disease (CVD): white matter hyperintensities, brain infarcts, and cerebral …

[HTML][HTML] Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

G Davies, M Lam, SE Harris, JW Trampush… - Nature …, 2018 - nature.com
General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …

Metformin use is associated with slowed cognitive decline and reduced incident dementia in older adults with type 2 diabetes: the Sydney memory and ageing study

K Samaras, S Makkar, JD Crawford, NA Kochan… - Diabetes …, 2020 - Am Diabetes Assoc
OBJECTIVE Type 2 diabetes (diabetes) is characterized by accelerated cognitive decline
and higher dementia risk. Controversy exists regarding the impact of metformin, which is …

[HTML][HTML] Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia

RER Slot, SAM Sikkes, J Berkhof, H Brodaty… - Alzheimer's & …, 2019 - Elsevier
Introduction In this multicenter study on subjective cognitive decline (SCD) in community-
based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease …

[HTML][HTML] A comparison of machine learning methods for survival analysis of high-dimensional clinical data for dementia prediction

A Spooner, E Chen, A Sowmya, P Sachdev… - Scientific reports, 2020 - nature.com
Data collected from clinical trials and cohort studies, such as dementia studies, are often
high-dimensional, censored, heterogeneous and contain missing information, presenting …

[HTML][HTML] Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

I De Rojas, S Moreno-Grau, N Tesi… - Nature …, 2021 - nature.com
Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and
together with polygenetic risk stratification can contribute towards planning of feasible and …

[HTML][HTML] The prevalence of mild cognitive impairment in diverse geographical and ethnocultural regions: the COSMIC collaboration

PS Sachdev, DM Lipnicki, NA Kochan, JD Crawford… - PloS one, 2015 - journals.plos.org
Background Changes in criteria and differences in populations studied and methodology
have produced a wide range of prevalence estimates for mild cognitive impairment (MCI) …