Antibiotic failure: Beyond antimicrobial resistance

C de la Fuente-Nunez, A Cesaro… - Drug Resistance Updates, 2023 - Elsevier
Despite significant progress in antibiotic discovery, millions of lives are lost annually to
infections. Surprisingly, the failure of antimicrobial treatments to effectively eliminate …

Endophytes: a uniquely tailored source of potential antibiotic adjuvants

AY Moussa - Archives of Microbiology, 2024 - Springer
Multidrug microbial resistance is risking an annual loss of more than 10 million people'lives
by 2050. Solutions include the rational use of antibiotics and the use of drugs that reduce …

In silico molecular targets, docking, dynamics simulation and physiologically based pharmacokinetics modeling of oritavancin

TH Fatoki, TC Balogun, AE Ojewuyi, AC Omole… - BMC Pharmacology and …, 2024 - Springer
Introduction Oritavancin is a semi-synthetic lipoglycopeptide antibiotic primarily used to treat
serious infections caused by Gram-positive bacteria. The aim of this study was to elucidate …