Transition metal-catalysed cross-coupling is one of the most powerful synthetic methods and
has led to vast improvements in the synthesis of pharmaceuticals, agrochemicals and …

Cyclopropanes are important substructures in natural products and pharmaceuticals.
Although traditional methods for their incorporation rely on cyclopropanation of an existing …

This Perspective describes general methods for the preparation of polyfunctional zinc
organometallics and their use in Negishi cross-coupling reactions. Recent advances …

Herein, we present an undirected para-selective two-step C–H alkylation of complex arenes
useful for late-stage functionalization. The combination of a site-selective C–H …

Palladium catalysts have become central to modern organic synthesis, particularly in the
context of cross‐coupling reactions to form C− C and C‐heteroatom bonds. The …

New approaches to the Pd-catalysis employing palladacycle precatalysts have been
recently developed. Breakthroughs in this area using 2-aminobiphenyl palladacycle …

Full control over multiple competing coupling sites would enable straightforward access to
densely functionalized compound libraries. Historically, the site selection in Pd0‐catalyzed …

A protocol for the stereospecific coupling of chiral secondary and tertiary boronic esters with
lithiated N-heteroaromatics is described. The process involves initial boronate complex …

We report the Pd-catalyzed arylation of very hindered α, α, α-trisubstituted primary amines.
Kinetics-based mechanistic analysis and rational design have led to the development of two …

Disclosed herein is the first general chemo‐and site‐selective alkylation of C− Br bonds in
the presence of COTf, C− Cl and other potentially reactive functional groups, using the air …