Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …

Reactive oxygen species (ROS) are integral components of multiple cellular pathways even
though excessive or inappropriately localized ROS damage cells. ROS function as anti …

The nucleotide-binding oligomerization domain (NOD)-like receptor pyrin domain containing
3 (NLRP3) responds to a vast variety of stimuli, and activated NLRP3 forms an …

Abstract NLRP3/IL-1β activation via thioredoxin (TRX)/thioredoxin-interacting protein
(TXNIP) following mitochondria ROS (mtROS) overproduction plays a key role in …

Inflammasomes are multiprotein innate immune complexes that regulate caspase-
dependent inflammation and cell death. Pattern recognition receptors, such as nucleotide …

Significance: Inflammasomes are multiprotein complexes localized within the cytoplasm of
the cell that are responsible for the maturation of proinflammatory cytokines such as …

Significance: Inflammasomes are cytosolic multiprotein complexes that mediate innate
immune pathways. Inflammasomes activate inflammatory caspases and regulate …

There is an increasing prevalence of Vascular Cognitive Impairment (VCI) worldwide, and
several studies have suggested that Chronic Cerebral Hypoperfusion (CCH) plays a critical …

In response to inflammatory stimuli, immune cells reconfigure their metabolism and
bioenergetics to generate energy and substrates for cell survival and to launch immune …

The nod-like receptor protein 3 (NLRP3) inflammasome has a critical role in inflammation
damage in ischemic injury, and the activation of the inflammasome is closely related to the …