Tuberculous meningitis: pathogenesis, immune responses, diagnostic challenges, and the potential of biomarker-based approaches

CM Manyelo, RS Solomons, G Walzl… - Journal of clinical …, 2021 - Am Soc Microbiol
Tuberculous meningitis (TBM) is the most devastating form of tuberculosis (TB), causing
high mortality or disability. Clinical management of the disease is challenging due to …

Sepsis and other infectious disease emergencies in the elderly

SY Liang - Emergency Medicine Clinics, 2016 - emed.theclinics.com
The world is aging. The number of individuals aged 60 years and older is expected to
increase globally from 841 million in 2013 to more than 2 billion by 2050. 1 In the United …

[HTML][HTML] Aseptic and bacterial meningitis: evaluation, treatment, and prevention

HR Mount, SD Boyle - American family physician, 2017 - aafp.org
The etiologies of meningitis range in severity from benign and self-limited to life-threatening
with potentially severe morbidity. Bacterial meningitis is a medical emergency that requires …

Aseptic meningitis in adults and children: Diagnostic and management challenges

B Shukla, EA Aguilera, L Salazar, SH Wootton… - Journal of clinical …, 2017 - Elsevier
Background Aseptic meningitis represents a common diagnostic and management dilemma
to clinicians. Objectives To compare the clinical epidemiology, diagnostic evaluations …

Diagnosis and treatment of central nervous system infections in the emergency department

M Dorsett, SY Liang - Emergency Medicine Clinics, 2016 - emed.theclinics.com
A key clinical responsibility of the emergency physician is to consider the “worst case
scenario” for a given chief complaint. When it comes to infections of the central nervous …

Cranial imaging before lumbar puncture in adults with community-acquired meningitis: clinical utility and adherence to the Infectious Diseases Society of America …

L Salazar, R Hasbun - Clinical infectious diseases, 2017 - academic.oup.com
Abstract Background. The Infectious Diseases Society of America (IDSA) guidelines
delineate criteria for the use of computed tomography (CT) scan of the head before lumbar …

Clinical epidemiology, risk factors, and outcomes of encephalitis in older adults

MA Hansen, MS Samannodi… - Clinical Infectious …, 2020 - academic.oup.com
Background Encephalitis is associated with significant morbidity and mortality, with unknown
etiologies in the majority of patients. Large prognostic studies evaluating elderly patients are …

[HTML][HTML] Acute versus subacute community-acquired meningitis: analysis of 611 patients

T Sulaiman, L Salazar, R Hasbun - Medicine, 2017 - journals.lww.com
Community-acquired meningitis can be classified into acute and subacute presentations by
the duration of illness of≤ or> 5 days, respectively. There are currently no studies …

[HTML][HTML] Usefulness of blood and cerebrospinal fluid laboratory testing to predict bacterial meningitis in the emergency department

A Julián-Jiménez, MI Morales-Casado - Neurología (English Edition), 2019 - Elsevier
Introduction The classic clinical presentation of bacterial meningitis (BM) is observed in less
than half of the cases in adults, and symptoms are less specific in children, the elderly or …

[HTML][HTML] The diagnostic utility of the “Thwaites' system” and “lancet consensus scoring system” in tuberculous vs. non-tuberculous subacute and chronic meningitis …

T Sulaiman, S Medi, H Erdem, S Senbayrak… - BMC Infectious …, 2020 - Springer
Background Tuberculous meningitis (TBM) represents a diagnostic and management
challenge to clinicians. The “Thwaites' system” and “Lancet consensus scoring system” are …