Bone is a multi-skilled tissue, protecting major organs, regulating calcium phosphate
balance and producing hormones. Its development during childhood determines height and …

Humans are spending an increasing amount of time in space, where exposure to conditions
of microgravity causes 1–2% bone loss per month in astronauts. Through data collected …

Wolff's law and the Utah Paradigm of skeletal physiology state that bone architecture adapts
to mechanical loads. These models predict the existence of a mechanostat that links strain …

Disuse osteoporosis describes a state of bone loss due to local skeletal unloading or
systemic immobilization. This review will discuss advances in the field that have shed light …

This review describes the role of bone cells and their surrounding matrix in maintaining
bone strength through the process of bone remodeling. Subsequently, this work focusses on …

Long-duration bed rest is widely employed to simulate the effects of microgravity on various
physiological systems, especially for studies of bone, muscle, and the cardiovascular …

During bone resorption, abundant factors previously buried in the bone matrix are released
into the bone marrow microenvironment, which results in recruitment and differentiation of …

The field of human space travel is in the midst of a dramatic revolution. Upcoming missions
are looking to push the boundaries of space travel, with plans to travel for longer distances …

Many biological tissues, such as wood and bone, are fiber composites with a hierarchical
structure. Their exceptional mechanical properties are believed to be due to a functional …

The Bioarchaeology of Metabolic Bone Disease, Second Edition is a comprehensive source
dedicated to better understanding this group of conditions that have significant …