Depression has become one of the most commonly prevalent neuropsychiatric disorders,
and the main characteristics of depression are sleep disorders and melatonin secretion …

Two‐pore‐domain potassium (K2P) channels are widespread in the nervous system and
play a critical role in maintaining membrane potential in neurons and glia. They have been …

Background RNA interference (RNAi) is a powerful technique to effectively silence or knock
down gene function in mammalian cells. For better cell-type RNAi experiments in vivo, AAV …

Most of the animal studies using inflammation-induced cognitive change have relied on
behavioral testing without objective and biologically solid methods to quantify the severity of …

Mature astrocytes are characterized by a K+ conductance (passive conductance) that
changes with a constant slope with voltage, which is involved in K+ homeostasis in the …

The two-pore domain K2P subunits form background (leak) potassium channels, which are
characterized by constitutive, although not necessarily constant activity, at all membrane …

Major depressive disorder (MDD) refers to a widespread psychiatric disorder. Astrocytes
play a pivotal role in regulating inflammation which is a well-acknowledged key component …

Introduction The two‐pore domain potassium channel TREK‐1 is a member of background
K+ channels that are thought to provide baseline regulation of membrane excitability …

Astrocytes, the most abundant cell type in the brain, are non-excitable cells and play critical
roles in brain function. Mature astrocytes typically exhibit a linear current–voltage …

Epilepsy with comorbid depression has recently attracted increasing attention. Temporal
lobe epilepsy (TLE) may represent an increased risk of developing depression, especially if …