Genome instability is a hallmark of cancer, and DNA replication is the most vulnerable
cellular process that can lead to it. Any condition leading to high levels of DNA damage will …

Human cancers share properties referred to as hallmarks, among which sustained
proliferation, escape from apoptosis, and genomic instability are the most pervasive. The …

Deletions and duplications of chromosomal segments (copy number variants, CNVs) are a
major source of variation between individual humans and are an underlying factor in human …

The mechanisms underlying the low efficiency of reprogramming somatic cells into induced
pluripotent stem (iPS) cells are poorly understood. There is a clear need to study whether …

Ever since initial suggestions that instability at common fragile sites (CFSs) could be
responsible for chromosome rearrangements in cancers, CFSs and associated genes have …

The molecular mechanisms underlying major phenotypic changes that have evolved
repeatedly in nature are generally unknown. Pelvic loss in different natural populations of …

Telomeres protect chromosome ends through the interaction of telomeric repeats with
shelterin, a protein complex that represses DNA damage signaling and DNA repair …

Repeated elements can be widely abundant in eukaryotic genomes, composing more than
50% of the human genome, for example. It is possible to classify repeated sequences into …

Several inherited syndromes in humans are associated with cancer predisposition. The
gene products defective in two of these disorders, BLM (a helicase defective in Bloom's …

Common fragile sites have long been identified by cytogeneticists as chromosomal regions
prone to breakage upon replication stress. They are increasingly recognized to be …