Large-scale sequencing of genomes has revealed that most enzyme families include
inactive homologues. These pseudoenzymes are often well conserved, implying a selective …

Mammalian chymotrypsin-like serine proteases (SPs) are one of the best-studied family of
enzymes with roles in a wide range of physiological processes, including digestion, blood …

Cell competition is a form of cell interaction that causes the elimination of less fit cells, or
losers, by wild-type (WT) cells, influencing overall tissue health. Several mutations can …

Dorsal closure is a key process during Drosophila morphogenesis that models cell sheet
movements in chordates, including neural tube closure, palate formation, and wound …

Understanding the molecular basis of wound healing and regeneration in vertebrates is one
of the main challenges in biology and medicine. This understanding will lead to medical …

Caspases are best characterized for their function in apoptosis. However, they also have
non-apoptotic functions such as apoptosis-induced proliferation (AiP), where caspases …

Phenoloxidase (PO) is a crucial component of the insect immune response against microbial
infection. In the tobacco hornworm Manduca sexta, PO is generated from its precursor …

The Jun‐N‐terminal Kinase pathway (JNK), known also as stress activated protein kinase
pathway (SAPK), is an eukaryotic evolutionarily conserved signaling pathway. From a …

In metazoan development, the precise mechanisms that regulate the completion of
morphogenesis according to a developmental timetable remain elusive. The Drosophila …

The adaptable transcriptional response to changes in food availability not only ensures
animal survival but also lets embryonic development progress. Interestingly, the CNS is …