Pulmonary hypertension (PH) is a serious disease characterized by various degrees of
pulmonary vasoconstriction and progressive fibroproliferative remodeling and inflammation …

Mechanosensitive ion channels sense mechanical stimuli applied directly to the cellular
membranes or indirectly through their tethered components, provoking cellular …

Capillaries are equipped to sense neurovascular coupling agents released onto the outer
wall of a capillary, translating these external signals into electrical/Ca2+ changes that play a …

Background: Mutations in PIEZO1 (Piezo type mechanosensitive ion channel component 1)
cause human lymphatic malformations. We have previously uncovered an ORAI1 (ORAI …

Piezo is a mechanosensitive cation channel responsible for stretch-mediated Ca2+ and Na+
influx in multiple types of cells. Little is known about the functional role of Piezo1 in the lung …

Background and Purpose Piezo1 channels are mechanosensitive cationic channels that are
activated by mechanical stretch or shear stress. Endothelial Piezo1 activation by shear …

Arterial Vascular smooth muscle cells (VSMCs) play a central role in the onset and
progression of atherosclerosis. Upon exposure to pathological stimuli, they can take on …

Since the recent discovery of the mechanosensitive Piezo1 channels, many studies have
addressed the role of the channel in various physiological or even pathological processes of …

Intervertebral disc degeneration (IVDD) is one of the most prevalent spinal degenerative
disorders and imposes places heavy medical and economic burdens on individuals and …

Proper regulation of ion balance across the intestinal epithelium is essential for
physiological functions, while ion imbalance causes intestinal disorders with dire health …