[HTML][HTML] The role of curcumin in cancer treatment

V Zoi, V Galani, GD Lianos, S Voulgaris, AP Kyritsis… - Biomedicines, 2021 - mdpi.com
Curcumin is a polyphenol extracted from the rhizomes of the turmeric plant, Curcuma longa
which has anti-inflammatory, and anticancer properties. Chronic inflammation is associated …

Versatile role of curcumin and its derivatives in lung cancer therapy

M Ashrafizadeh, M Najafi, P Makvandi… - Journal of cellular …, 2020 - Wiley Online Library
Lung cancer is a main cause of death all over the world with a high incidence rate.
Metastasis into neighboring and distant tissues as well as resistance of cancer cells to …

Curcumin production and bioavailability: A comprehensive review of curcumin extraction, synthesis, biotransformation and delivery systems

L Yixuan, MA Qaria, S Sivasamy, S Jianzhong… - Industrial Crops and …, 2021 - Elsevier
Curcuma longa, a perennial herb of the family genus turmeric, was used as a natural
pigment in the food industry in the ancient era. The medicinal efficacy and function of …

[HTML][HTML] Curcumin and its analogs in non-small cell lung cancer treatment: Challenges and expectations

C Tang, J Liu, C Yang, J Ma, X Chen, D Liu, Y Zhou… - Biomolecules, 2022 - mdpi.com
Researchers have made crucial advances in understanding the pathogenesis and
therapeutics of non-small cell lung cancer (NSCLC), improving our understanding of lung …

The second‐generation curcumin analogue RL71 elicits G2/M cell cycle arrest and apoptosis in canine osteosarcoma cells

B Kelly, D Thamm, RJ Rosengren - … and Comparative Oncology, 2023 - Wiley Online Library
Canine osteosarcoma is an aggressive cancer, comprising 85% of canine bone neoplasms.
Current treatment practices of surgery and chemotherapy increase 1‐year survival by only …

Curcumin-Derived Heterocycles as Anticancer Agents. A Systematic Review.

A Bahmani, Z Najafi, G Chehardoli - Organic Preparations and …, 2022 - Taylor & Francis
Curcumin is of intensive current interest for its biological activities, including the prevention
and treatment of cancer. Curcumin induces apoptosis and stops the cell cycle in different …

[HTML][HTML] Mechanisms of synergistic suppression of ALK-positive lung cancer cell growth by the combination of ALK and SHP2 inhibitors

MA Berry, AR Bland, JC Ashton - Scientific Reports, 2023 - nature.com
Lung cancer is a major cause of cancer-related deaths. Alectinib is the first line of treatment
for patients with ALK-positive lung cancer, but the survival rate beyond 2–3 years is low. Co …

The effect of metformin in EML4-ALK+ lung cancer alone and in combination with crizotinib in cell and rodent models

AR Bland, N Shrestha, RL Bower, RJ Rosengren… - Biochemical …, 2021 - Elsevier
Cell based studies have suggested that the diabetes drug metformin may combine with the
anaplastic lymphoma kinase receptor (ALK) inhibitor crizotinib to increase ALK positive lung …

[PDF][PDF] 姜黄素及其衍生物的作用及机制

王海英, 张宇琪, 孙昊天, 张冉, 亚白柳 - 生理科学进展, 2022 - physiol.bjmu.edu.cn
摘要姜黄素提取自中药姜黄根茎, 分子式为C21H20O6, 是一种亲脂性生物活性多酚.
姜黄素的毒副作用小并且具有广泛的药理活性, 可以通过多种作用机制达到抗肿瘤, 抗炎症 …

[HTML][HTML] 2-Chloro-4,6-bis{(E)-3-methoxy-4-[(4-methoxybenzyl)oxy]styryl}pyrimidine: Synthesis, Spectroscopic and Computational Evaluation

OA Chaves, V Sueth-Santiago, DCA Pinto… - Molbank, 2021 - mdpi.com
A novel curcumin analog namely 2-chloro-4, 6-bis {(E)-3-methoxy-4-[(4-methoxybenzyl) oxy]-
styryl} pyrimidine (compound 7) was synthesized by three-step reaction. The condensation …