Numerous post-translational modifications (PTMs) govern the collective metabolism of a cell
through altering the structure and functions of proteins. The action of the most prevalent …

Peptidylarginine deiminases (PADs) are calcium-dependent enzymes that mediate
citrullination, an irreversible post-translational modification (PTM). PAD enzymes have …

The systemic spread of malignancies and the risk of cancer-associated thrombosis are
major clinical challenges in cancer therapy worldwide. As an important post-translational …

Limited evidence has shed light on how aSYN proteins affect the oligodendrocyte
phenotype and pathogenesis in synucleinopathies that include Parkinson's disease (PD) …

Peptidylarginine deiminase (PADI) 2 catalyzes the post-translational conversion of peptidyl-
arginine to peptidyl-citrulline in a process called citrullination. However, the precise …

Cellular senescence is closely related to tissue aging including bone. Bone homeostasis is
maintained by the tight balance between bone-forming osteoblasts and bone-resorbing …

The post-translational modification of proteins expands the regulatory scope of the proteome
far beyond what is achievable through genome regulation. The field of protein citrullination …

Following central nervous system (CNS) demyelination, adult oligodendrocyte progenitor
cells (OPCs) can differentiate into new myelin-forming oligodendrocytes in a regenerative …

Oligodendrocytes are specialized cells that insulate and support axons with their myelin
membrane, allowing proper brain function. Here, we identify lamin A/C (LMNA/C) as …

Protein arginine deimination leading to the non-coded amino acid citrulline remains a key
question in the field of post-translational modifications ever since its discovery by Rogers …