[HTML][HTML] The cyclic AMP signaling pathway: Exploring targets for successful drug discovery
KUO Yan, LN Gao, YL Cui… - Molecular medicine …, 2016 - spandidos-publications.com
During development of disease, complex intracellular signaling pathways regulate an
intricate series of events, including resistance to external toxins, the secretion of cytokines …
intricate series of events, including resistance to external toxins, the secretion of cytokines …
[HTML][HTML] Epigenetics of host–pathogen interactions: the road ahead and the road behind
A growing body of evidence points towards epigenetic mechanisms being responsible for a
wide range of biological phenomena, from the plasticity of plant growth and development to …
wide range of biological phenomena, from the plasticity of plant growth and development to …
IGF2BP1 promotes SRF-dependent transcription in cancer in am6A- and miRNA-dependent manner
The oncofetal mRNA-binding protein IGF2BP1 and the transcriptional regulator SRF
modulate gene expression in cancer. In cancer cells, we demonstrate that IGF2BP1 …
modulate gene expression in cancer. In cancer cells, we demonstrate that IGF2BP1 …
[HTML][HTML] Polycomb repressive complex 1 generates discrete compacted domains that change during differentiation
Master regulatory genes require stable silencing by the polycomb group (PcG) to prevent
misexpression during differentiation and development. Some PcG proteins covalently modify …
misexpression during differentiation and development. Some PcG proteins covalently modify …
[HTML][HTML] Fatty acid oxidation protects cancer cells from apoptosis by increasing mitochondrial membrane lipids
YJ Li, JF Fahrmann, M Aftabizadeh, Q Zhao… - Cell reports, 2022 - cell.com
Overcoming resistance to chemotherapies remains a major unmet need for cancers, such as
triple-negative breast cancer (TNBC). Therefore, mechanistic studies to provide insight for …
triple-negative breast cancer (TNBC). Therefore, mechanistic studies to provide insight for …
[HTML][HTML] Acidosis drives the reprogramming of fatty acid metabolism in cancer cells through changes in mitochondrial and histone acetylation
C Corbet, A Pinto, R Martherus, JPS de Jesus, F Polet… - Cell metabolism, 2016 - cell.com
Bioenergetic preferences of cancer cells foster tumor acidosis that in turn leads to dramatic
reduction in glycolysis and glucose-derived acetyl-coenzyme A (acetyl-CoA). Here, we show …
reduction in glycolysis and glucose-derived acetyl-coenzyme A (acetyl-CoA). Here, we show …
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers and
shows resistance to any therapeutic strategy used. Here we tested small-molecule inhibitors …
shows resistance to any therapeutic strategy used. Here we tested small-molecule inhibitors …
GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer
P Martinelli, E Carrillo-de Santa Pau, T Cox, B Sainz… - Gut, 2017 - gut.bmj.com
Background and aims The role of GATA factors in cancer has gained increasing attention
recently, but the function of GATA6 in pancreatic ductal adenocarcinoma (PDAC) is …
recently, but the function of GATA6 in pancreatic ductal adenocarcinoma (PDAC) is …
MYC instructs and maintains pancreatic adenocarcinoma phenotype
The signature features of pancreatic ductal adenocarcinoma (PDAC) are its
fibroinflammatory stroma, poor immune activity, and dismal prognosis. We show that acute …
fibroinflammatory stroma, poor immune activity, and dismal prognosis. We show that acute …
p53 directly represses human LINE1 transposons
B Tiwari, AE Jones, CJ Caillet, S Das… - Genes & …, 2020 - genesdev.cshlp.org
Abstract p53 is a potent tumor suppressor and commonly mutated in human cancers.
Recently, we demonstrated that p53 genes act to restrict retrotransposons in germline …
Recently, we demonstrated that p53 genes act to restrict retrotransposons in germline …