Regulated cell death (RCD) in cancer: key pathways and targeted therapies

F Peng, M Liao, R Qin, S Zhu, C Peng, L Fu… - Signal transduction and …, 2022 - nature.com
Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …

Ferroptosis‐modulating small molecules for targeting drug‐resistant cancer: Challenges and opportunities in manipulating redox signaling

SC Koeberle, AP Kipp, H Stuppner… - Medicinal Research …, 2023 - Wiley Online Library
Ferroptosis is an iron‐dependent cell death program that is characterized by excessive lipid
peroxidation. Triggering ferroptosis has been proposed as a promising strategy to fight …

Ferroptosis and its role in chronic diseases

W Hu, K Liang, H Zhu, C Zhao, H Hu, S Yin - Cells, 2022 - mdpi.com
Ferroptosis, which has been widely associated with many diseases, is an iron-dependent
regulated cell death characterized by intracellular lipid peroxide accumulation. It exhibits …

Ferroptosis in gastrointestinal cancer: from mechanisms to implications

R Zhang, R Kang, D Tang - Cancer Letters, 2023 - Elsevier
Ferroptosis is a form of regulated cell death that is initiated by excessive lipid peroxidation
that results in plasma membrane damage and the release of damage-associated molecular …

Identification the ferroptosis-related gene signature in patients with esophageal adenocarcinoma

L Zhu, F Yang, L Wang, L Dong, Z Huang… - Cancer cell …, 2021 - Springer
Background Ferroptosis is a recently recognized non-apoptotic cell death that is distinct from
the apoptosis, necroptosis and pyroptosis. Considerable studies have demonstrated …

Ferroptosis in colorectal cancer: a future target?

H Yan, R Talty, O Aladelokun, M Bosenberg… - British Journal of …, 2023 - nature.com
Colorectal cancer (CRC) is the third leading cause of cancer deaths worldwide and is
characterised by frequently mutated genes, such as APC, TP53, KRAS and BRAF. The …

Curcumin and andrographis exhibit anti-tumor effects in colorectal cancer via activation of ferroptosis and dual suppression of glutathione peroxidase-4 and …

K Miyazaki, C Xu, M Shimada, A Goel - Pharmaceuticals, 2023 - mdpi.com
Colorectal cancer (CRC) is the leading cause of cancer-related deaths worldwide. The
limitations of current chemotherapeutic drugs in CRC include their toxicity, side effects, and …

[HTML][HTML] Ferroptosis-based nano delivery systems targeted therapy for colorectal cancer: insights and future perspectives

C Qiao, H Wang, Q Guan, M Wei, Z Li - Asian Journal of Pharmaceutical …, 2022 - Elsevier
There are limited options for patients who develop liver metastasis from colorectal cancer
(CRC), the leading cause of cancer-related mortality worldwide. Emerging evidence has …

Enhanced anti-cancer activity of andrographis with oligomeric proanthocyanidins through activation of metabolic and ferroptosis pathways in colorectal cancer

T Shimura, P Sharma, GG Sharma, JK Banwait… - Scientific Reports, 2021 - nature.com
The high degree of morbidity and mortality in colorectal cancer (CRC) patients is largely due
to the development of chemoresistance against conventional chemotherapeutic drugs. In …

Comprehensive analysis of immune infiltrates of ferroptosis‐related long noncoding RNA and prediction of colon cancer patient prognoses

W Chen, Y Chen, L Liu, Y Wu, P Fu… - Journal of …, 2022 - Wiley Online Library
Ferroptosis is a newly defined mode of programmed oxidative cell death. Knowledge of
ferroptosis‐related long noncoding (lnc) RNA in the tumor immune microenvironment of …