Targeting ferroptosis as a vulnerability in cancer

G Lei, L Zhuang, B Gan - Nature Reviews Cancer, 2022 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic
build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered …

Signaling pathways and targeted therapy for myocardial infarction

Q Zhang, L Wang, S Wang, H Cheng, L Xu… - Signal transduction and …, 2022 - nature.com
Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

A targetable CoQ-FSP1 axis drives ferroptosis-and radiation-resistance in KEAP1 inactive lung cancers

P Koppula, G Lei, Y Zhang, Y Yan, C Mao… - Nature …, 2022 - nature.com
Targeting ferroptosis, a unique cell death modality triggered by unrestricted lipid
peroxidation, in cancer therapy is hindered by our incomplete understanding of ferroptosis …

An overview of Nrf2 signaling pathway and its role in inflammation

S Saha, B Buttari, E Panieri, E Profumo, L Saso - Molecules, 2020 - mdpi.com
Inflammation is a key driver in many pathological conditions such as allergy, cancer,
Alzheimer's disease, and many others, and the current state of available drugs prompted …

Mechanistic insight into oxidative stress-triggered signaling pathways and type 2 diabetes

A Singh, R Kukreti, L Saso, S Kukreti - Molecules, 2022 - mdpi.com
Oxidative stress (OS) is a metabolic dysfunction mediated by the imbalance between the
biochemical processes leading to elevated production of reactive oxygen species (ROS) …

Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway

GH Chen, CC Song, K Pantopoulos, XL Wei… - Free Radical Biology …, 2022 - Elsevier
Ferroptosis is a regulated form of cell death induced by iron (Fe)-dependent lipid
peroxidation. At present, the underlying molecular mechanisms remain elusive. Herein, we …

Oxidative stress tolerance and antioxidant capacity of lactic acid bacteria as probiotic: a systematic review

T Feng, J Wang - Gut microbes, 2020 - Taylor & Francis
Lactic acid bacteria (LAB) are the most frequently used probiotics in fermented foods and
beverages and as food supplements for humans or animals, owing to their multiple …

Air pollution and its effects on the immune system

DA Glencross, TR Ho, N Camina… - Free Radical Biology …, 2020 - Elsevier
A well-functioning immune system is vital for a healthy body. Inadequate and excessive
immune responses underlie diverse pathologies such as serious infections, metastatic …

Plant protein-derived antioxidant peptides: Isolation, identification, mechanism of action and application in food systems: A review

C Wen, J Zhang, H Zhang, Y Duan, H Ma - Trends in Food Science & …, 2020 - Elsevier
Background In recent years, the antioxidant capacity of plant protein-derived peptides has
been depicted in a growing number of studies. Plant proteins have been considered as the …

Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis

L Rochette, G Dogon, E Rigal, M Zeller… - International journal of …, 2022 - mdpi.com
Regulated cell death (RCD) has a significant impact on development, tissue homeostasis,
and the occurrence of various diseases. Among different forms of RCD, ferroptosis is …