Targeting ferroptosis as a vulnerability in cancer
Ferroptosis is an iron-dependent form of regulated cell death that is triggered by the toxic
build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered …
build-up of lipid peroxides on cellular membranes. In recent years, ferroptosis has garnered …
Signaling pathways and targeted therapy for myocardial infarction
Q Zhang, L Wang, S Wang, H Cheng, L Xu… - Signal transduction and …, 2022 - nature.com
Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …
A targetable CoQ-FSP1 axis drives ferroptosis-and radiation-resistance in KEAP1 inactive lung cancers
Targeting ferroptosis, a unique cell death modality triggered by unrestricted lipid
peroxidation, in cancer therapy is hindered by our incomplete understanding of ferroptosis …
peroxidation, in cancer therapy is hindered by our incomplete understanding of ferroptosis …
An overview of Nrf2 signaling pathway and its role in inflammation
Inflammation is a key driver in many pathological conditions such as allergy, cancer,
Alzheimer's disease, and many others, and the current state of available drugs prompted …
Alzheimer's disease, and many others, and the current state of available drugs prompted …
Mechanistic insight into oxidative stress-triggered signaling pathways and type 2 diabetes
Oxidative stress (OS) is a metabolic dysfunction mediated by the imbalance between the
biochemical processes leading to elevated production of reactive oxygen species (ROS) …
biochemical processes leading to elevated production of reactive oxygen species (ROS) …
Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway
GH Chen, CC Song, K Pantopoulos, XL Wei… - Free Radical Biology …, 2022 - Elsevier
Ferroptosis is a regulated form of cell death induced by iron (Fe)-dependent lipid
peroxidation. At present, the underlying molecular mechanisms remain elusive. Herein, we …
peroxidation. At present, the underlying molecular mechanisms remain elusive. Herein, we …
Oxidative stress tolerance and antioxidant capacity of lactic acid bacteria as probiotic: a systematic review
T Feng, J Wang - Gut microbes, 2020 - Taylor & Francis
Lactic acid bacteria (LAB) are the most frequently used probiotics in fermented foods and
beverages and as food supplements for humans or animals, owing to their multiple …
beverages and as food supplements for humans or animals, owing to their multiple …
Air pollution and its effects on the immune system
DA Glencross, TR Ho, N Camina… - Free Radical Biology …, 2020 - Elsevier
A well-functioning immune system is vital for a healthy body. Inadequate and excessive
immune responses underlie diverse pathologies such as serious infections, metastatic …
immune responses underlie diverse pathologies such as serious infections, metastatic …
Plant protein-derived antioxidant peptides: Isolation, identification, mechanism of action and application in food systems: A review
C Wen, J Zhang, H Zhang, Y Duan, H Ma - Trends in Food Science & …, 2020 - Elsevier
Background In recent years, the antioxidant capacity of plant protein-derived peptides has
been depicted in a growing number of studies. Plant proteins have been considered as the …
been depicted in a growing number of studies. Plant proteins have been considered as the …
Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis
L Rochette, G Dogon, E Rigal, M Zeller… - International journal of …, 2022 - mdpi.com
Regulated cell death (RCD) has a significant impact on development, tissue homeostasis,
and the occurrence of various diseases. Among different forms of RCD, ferroptosis is …
and the occurrence of various diseases. Among different forms of RCD, ferroptosis is …