The angiotensin-converting enzyme 2 (ACE2) is the host functional receptor for the new
virus SARS-CoV-2 causing Coronavirus Disease 2019. ACE2 is expressed in 72 different …

Cardiovascular disease (CVD) and cancer are the leading causes of death worldwide. With
an increasing number of the elderly population, and early cancer screening and treatment …

Rationale & Objective Patients with chronic kidney disease (CKD) may be at increased risk
for cancer. CKD may also be associated with worse cancer outcomes. This study examined …

In recent decades, dysregulation of proteases and atypical proteolysis have become
increasingly recognized as important hallmarks of cancer, driving community-wide efforts to …

Background Serum peptidases, such as angiotensin-converting enzyme (ACE), angiotensin-
converting enzyme-2 (ACE2), neutral endopeptidase (NEP), aminopeptidase N (APN), and …

Similarly to our healthy organs, the tumor tissue also constitutes an ecosystem. This implies
that stromal cells acquire an altered phenotype in tandem with tumor cells, thereby …

Background Chronic kidney disease (CKD) is inherently a complex immune-inflammatory
condition, and heightened inflammation and immune dysfunction are closely related to an …

The renin-angiotensin-aldosterone system (RAAS), is an old system with new fundamental
roles in cancer biology which influences cell growth, migration, death, and metastasis. RAAS …

Cancer remains one of the most common causes of death and disability and represents a
major economic burden in industrialized nations. The renin-angiotensin system (RAS) has …

Diabetic retinopathy is the leading cause of blindness in working age adults, and is
projected to be a significant future health concern due to the rising incidence of diabetes …