Studies of mammalian development have advanced our understanding of the genetic,
epigenetic, and cellular processes that orchestrate embryogenesis and have uncovered …

Endogenous retroviruses (ERVs) are evolutionary remnants of retroviral infections in which
the viral genome became embedded as a dormant regulatory element within the host …

Noncoding DNA is central to our understanding of human gene regulation and complex
diseases,, and measuring the evolutionary sequence constraint can establish the functional …

Cys2-His2 zinc finger genes (ZNFs) form the largest family of transcription factors in
metazoans. ZNF evolution is highly dynamic and characterized by the rapid expansion and …

Krüppel-associated box (KRAB) domain-containing zinc finger proteins (KZFPs) are one of
the largest groups of transcription factors encoded by tetrapods, with 378 members in …

The placenta is a fast-evolving organ with large morphological and histological differences
across eutherians, but the genetic changes driving placental evolution have not been fully …

Transposable elements (TE) are repetitive genomic elements that harbor binding sites for
human transcription factors (TF). A regulatory role for TEs has been suggested in embryonal …

Over the past few decades, many attempts have been made to capture different states of
pluripotency in vitro. Naive and primed pluripotent stem cells, corresponding to the …

In sexually reproducing organisms, life begins with the fusion of transcriptionally silent
gametes, the oocyte and sperm. Although initiation of transcription in the embryo, known as …

Mammalian genomes harbor abundant transposable elements (TEs) and their remnants,
with numerous epigenetic repression mechanisms enacted to silence TE transcription …