Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

The inner ear is a structurally complex vertebrate organ built to encode sound, motion, and
orientation in space. Given its complexity, it is not surprising that inner ear dysfunction is a …

Breaking symmetry in populations of uniform cells, to induce adoption of an alternative cell
fate, is an essential developmental mechanism. Similarly, domain and boundary …

Sensory hair cells are mechanoreceptors of the auditory and vestibular systems and are
crucial for hearing and balance. In adult mammals, auditory hair cells are unable to …

The mammalian cochlea is a remarkable sensory organ, capable of perceiving sound over a
range of 1012 in pressure, and discriminating both infrasonic and ultrasonic frequencies in …

The otocyst harbors progenitors for most cell types of the mature inner ear. Developmental
lineage analyses and gene expression studies suggest that distinct progenitor populations …

INTRODUCTION Spatial patterning in developing multicellular organisms relies on
positional cues and cell-cell interactions. Stereotyped sensory organ arrangements in …

The organ of Corti, located within the mammalian cochlea, contains a precise mosaic of hair
cells (HC) and supporting cells (SC), the patterning of which is critical for auditory function …

Sensorineural hearing loss is the most common sensory deficit in humans. Despite the
global scale of the problem, only limited treatment options are available today. The …

Background: Damage or destruction of sensory hair cells in the inner ear leads to hearing or
balance deficits that can be debilitating, especially in older adults. Unfortunately, the …