Molecular control of oligodendrocyte development

B Elbaz, B Popko - Trends in neurosciences, 2019 - cell.com
Myelin is a multilayer lipid membrane structure that wraps and insulates axons, allowing for
the efficient propagation of action potentials. During developmental myelination of the …

The role of miRNAs in multiple sclerosis pathogenesis, diagnosis, and therapeutic resistance

AS Doghish, O Elazazy, HH Mohamed… - … -Research and Practice, 2023 - Elsevier
In recent years, microRNAs (miRNAs) have gained increased attention from researchers
around the globe. Although it is twenty nucleotides long, it can modulate several gene …

MicroRNA alteration, application as biomarkers, and therapeutic approaches in neurodegenerative diseases

TPN Nguyen, M Kumar, E Fedele, G Bonanno… - International journal of …, 2022 - mdpi.com
MicroRNAs (miRNAs) are essential post-transcriptional gene regulators involved in various
neuronal and non-neuronal cell functions and play a key role in pathological conditions …

From OPC to oligodendrocyte: an epigenetic journey

A Tiane, M Schepers, B Rombaut, R Hupperts… - Cells, 2019 - mdpi.com
Oligodendrocytes provide metabolic and functional support to neuronal cells, rendering
them key players in the functioning of the central nervous system. Oligodendrocytes need to …

[HTML][HTML] Small non-coding RNAs as important players, biomarkers and therapeutic targets in multiple sclerosis: A comprehensive overview

E Piket, GY Zheleznyakova, L Kular, M Jagodic - Journal of autoimmunity, 2019 - Elsevier
Multiple sclerosis (MS) is a leading cause of progressive disability among young adults
caused by inflammation, demyelination and axonal loss in the central nervous system. Small …

MicroRNAs, multiple sclerosis, and depression

H Wang - International Journal of Molecular Sciences, 2021 - mdpi.com
Multiple sclerosis (MS) is a chronic disease of the central nervous system that affects the
brain and spinal cord. There are several disease courses in MS including relapsing …

Remyelination in multiple sclerosis from the miRNA perspective

K Maciak, A Dziedzic, J Saluk - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
Remyelination relies on the repair of damaged myelin sheaths, involving microglia cells,
oligodendrocyte precursor cells (OPCs), and mature oligodendrocytes. This process drives …

Multiple sclerosis: roles of miRNA, lcnRNA, and circRNA and their implications in cellular pathways

GL Cipriano, G Schepici, E Mazzon… - International Journal of …, 2024 - mdpi.com
Multiple sclerosis (MS) is a degenerative condition characterized by axonal damage and
demyelination induced by autoreactive immune cells that occur in the Central Nervous …

In vivo silencing of miR‐125a‐3p promotes myelin repair in models of white matter demyelination

D Marangon, E Boda, R Parolisi, C Negri, C Giorgi… - Glia, 2020 - Wiley Online Library
In the last decade, microRNAs have been increasingly recognized as key modulators of glial
development. Recently, we identified miR‐125a‐3p as a new player in oligodendrocyte …

Extracellular vesicle‐associated cholesterol supports the regenerative functions of macrophages in the brain

S Vanherle, J Guns, M Loix, F Mingneau… - Journal of …, 2023 - Wiley Online Library
Macrophages play major roles in the pathophysiology of various neurological disorders,
being involved in seemingly opposing processes such as lesion progression and resolution …