When cell surface receptors engage their cognate ligands in the extracellular space, they
become competent to transmit potent signals to the inside of the cell, thereby instigating …

The epidermal growth factor receptor (EGFR) triggers the activation of many intracellular
signals that control cell proliferation, growth, survival, migration, and differentiation. Given its …

Cancer stem cell (CSC) cluster of triple-negative breast cancer (TNBC) is suggested to be
responsible for therapy resistance, metastatic process and cancer recurrence, yet the …

Glioma stem cells (GSCs) comprise a small subpopulation of glioblastoma multiforme cells
that contribute to therapy resistance, poor prognosis, and tumor recurrence. Protective …

Photodynamic therapy (PDT) is a potential synergistic approach to chemotherapy for treating
ovarian cancer, the most lethal gynecologic malignancy. Here we used M13 bacteriophage …

Autophagy is a naturally occurring programed cellular catabolic process stimulated by
cellular stress for energy homeostasis maintenance and elimination of harmful substances. It …

Epidermal growth factor receptor (EGFR) plays a crucial role in human non–small cell lung
cancer (NSCLC) tumorigenesis. In this study, oxymatrine was identified as an EGFR …

Liver cancer is among the most common types of cancer worldwide. The aim of the present
study was to investigate whether the phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) …

Spinosyn A (SPA), derived from a soil microorganism, Saccharopolyspora spinosa, and its
derivative, LM2I, has potential inhibitory effects on a variety of cancer cells. However, the …

Clathrin-mediated endocytosis (CME) regulates the uptake of cell-surface receptors as well
as their downstream signaling activities. We recently reported that signaling can reciprocally …