Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell
death and programmed apoptotic, and are crucial for cell metabolism and survival …

Mitochondria are central hubs of cellular metabolism that also play key roles in signaling
and disease. It is therefore fundamentally important that mitochondrial quality and activity …

Mitochondrial-derived vesicles (MDVs) are implicated in diverse physiological processes—
for example, mitochondrial quality control—and are linked to various neurodegenerative …

ER-phagy (reticulophagy) defines the degradation of portions of the endoplasmic reticulum
(ER) within lysosomes or vacuoles. It is part of the self-digestion (ie, autophagic) programs …

Understanding the mechanisms governing selective turnover of mutation-bearing mtDNA is
fundamental to design therapeutic strategies against mtDNA diseases. Here, we show that …

Mitochondrial DNA (mtDNA) encodes essential subunits of the oxidative phosphorylation
system, but is also a major damage-associated molecular pattern (DAMP) that engages …

Selective clearance of organelles, including endoplasmic reticulum (ER) and mitochondria,
by autophagy plays an important role in cell health. Here, we describe a developmentally …

Mitochondria are crucial organelles that play a central role in various cell signaling and
metabolic pathways. A healthy mitochondrial population is maintained through a series of …

Mitochondrial structure often determines the function of these highly dynamic,
multifunctional, eukaryotic organelles, which are essential for maintaining cellular health …

Mitochondria play critical roles in cellular metabolism and to maintain their integrity, they are
regulated by several quality control pathways, including mitophagy. During BNIP3/BNIP3L …