Idiosyncratic drug-induced liver injury (DILI) is a type of hepatic injury caused by an
uncommon drug adverse reaction that can develop to conditions spanning from …

Methods: We systematically reviewed adverse events among treatment-naive HIV-positive
adults and children receiving either NVP or EFV as part of first-line antiretroviral therapy. The …

Antiretroviral drug-related liver injury (ARLI) is a common cause of morbidity, mortality and
treatment discontinuation in HIV-infected patients [1]. Prevention and management of ARLI …

Alzheimer's disease is the most common form of dementia and is the only top 10 cause of
death in the United States that lacks disease‐altering treatments. It is a complex disorder …

Objectives The aim of this study was to investigate the frequency of CYP2B6 polymorphisms
(according to ethnicity) and the influence of heterozygosity and homozygosity on plasma …

Significant intra-and interindividual variability has been observed in response to use of
pharmacological agents in treatment of HIV infection. Treatment of HIV infection is limited by …

Associations have been reported between an MDR1 variant and responses to
nonnucleoside reverse-transcriptase inhibitors. We explored associations between MDR1 …

There is considerable evidence that susceptibility to idiosyncratic drug-induced liver injury
(DILI) is genetically determined. Though genetic associations with DILI have been reported …

The introduction of highly active antiretroviral therapy (HAART) as standard of care has
changed the natural history of HIV infection into a manageable chronic disease requiring …

Many drugs used for the treatment of HIV disease (including the associated opportunistic
infections) can cause drug hypersensitivity reactions, which vary in severity, clinical …