Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer's Disease: Preclinical to Clinical Trial Insights
K Nagori, KT Nakhate, K Yadav, Ajazuddin… - Future …, 2023 - mdpi.com
Alzheimer's disease (AD) is a progressive, multifactorial, and unremitting neurodegenerative
disease characterized by memory loss, personality changes, and cognitive impairment. It …
disease characterized by memory loss, personality changes, and cognitive impairment. It …
Unveiling the impact of Aging on BBB and Alzheimer's disease: Factors and Therapeutic implications
Alzheimer's disease (AD) is a highly prevalent neurodegenerative condition that has
devastating effects on individuals, often resulting in dementia. AD is primarily defined by the …
devastating effects on individuals, often resulting in dementia. AD is primarily defined by the …
Microorganism-derived molecules as enzyme inhibitors to target Alzheimer's diseases pathways
Alzheimer's disease (AD) is the most common form of dementia. It increases the risk of other
serious diseases and causes a huge impact on individuals, families, and socioeconomics …
serious diseases and causes a huge impact on individuals, families, and socioeconomics …
Protein aggregation and neurodegenerative disease: structural outlook for the novel therapeutics
Before the controversial approval of humanized monoclonal antibody lecanemab, which
binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for …
binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for …
Cell-penetrating peptides: Promising therapeutics and drug-delivery systems for neurodegenerative diseases
M Pirhaghi, F Mamashli… - Molecular …, 2024 - ACS Publications
Currently, one of the most significant and rapidly growing unmet medical challenges is the
treatment of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's …
treatment of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's …
Anti-amyloid potential of some phytochemicals against Aβ-peptide and α-synuclein, tau, prion, and Huntingtin protein
Highlights•According to in-vitro and in-silico investigations, the phytochemicals discussed in
this review show anti-amyloid potential.•Some phytochemicals have blood brain barrier …
this review show anti-amyloid potential.•Some phytochemicals have blood brain barrier …
[HTML][HTML] Antisense therapy: a potential breakthrough in the treatment of neurodegenerative diseases
R Romano, C Bucci - Neural Regeneration Research, 2024 - journals.lww.com
Neurodegenerative diseases are a group of disorders characterized by the progressive
degeneration of neurons in the central or peripheral nervous system. Currently, there is no …
degeneration of neurons in the central or peripheral nervous system. Currently, there is no …
[HTML][HTML] Harnessing the potential of mesenchymal stem cells–derived exosomes in degenerative diseases
Mesenchymal stem cells (MSCs) have gained attention as a promising therapeutic approach
in both preclinical and clinical osteoarthritis (OA) settings. Various joint cell types, such as …
in both preclinical and clinical osteoarthritis (OA) settings. Various joint cell types, such as …
Mannich reaction mediated derivatization of chromones and their biological evaluations as putative multipotent ligands for the treatment of Alzheimer's disease
N Kumar, K Jangid, V Kumar, B Devi, T Arora… - RSC Medicinal …, 2024 - pubs.rsc.org
Alzheimer's disease (AD) is a complex neurological disorder and multiple pathways are
associated with its pathology. Currently available single-targeting drugs are found to be …
associated with its pathology. Currently available single-targeting drugs are found to be …
Synergistic neuroprotection by phytocompounds of Bacopa monnieri in scopolamine-induced Alzheimer's disease mice model
Background Millions of people around the globe are affected by Alzheimer's disease (AD).
This crippling condition has no treatment despite intensive studies. Some phytocompounds …
This crippling condition has no treatment despite intensive studies. Some phytocompounds …