Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer's Disease: Preclinical to Clinical Trial Insights

K Nagori, KT Nakhate, K Yadav, Ajazuddin… - Future …, 2023 - mdpi.com
Alzheimer's disease (AD) is a progressive, multifactorial, and unremitting neurodegenerative
disease characterized by memory loss, personality changes, and cognitive impairment. It …

Unveiling the impact of Aging on BBB and Alzheimer's disease: Factors and Therapeutic implications

VK Nelson, NK Jha, MV Nuli, S Gupta, S Kanna… - Ageing research …, 2024 - Elsevier
Alzheimer's disease (AD) is a highly prevalent neurodegenerative condition that has
devastating effects on individuals, often resulting in dementia. AD is primarily defined by the …

Microorganism-derived molecules as enzyme inhibitors to target Alzheimer's diseases pathways

TH Nguyen, SL Wang, VB Nguyen - Pharmaceuticals, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common form of dementia. It increases the risk of other
serious diseases and causes a huge impact on individuals, families, and socioeconomics …

Protein aggregation and neurodegenerative disease: structural outlook for the novel therapeutics

S Arar, MA Haque, R Kayed - Proteins: Structure, Function, and …, 2023 - Wiley Online Library
Before the controversial approval of humanized monoclonal antibody lecanemab, which
binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for …

Cell-penetrating peptides: Promising therapeutics and drug-delivery systems for neurodegenerative diseases

M Pirhaghi, F Mamashli… - Molecular …, 2024 - ACS Publications
Currently, one of the most significant and rapidly growing unmet medical challenges is the
treatment of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's …

Anti-amyloid potential of some phytochemicals against Aβ-peptide and α-synuclein, tau, prion, and Huntingtin protein

JP Jerom, S Madhukumar, RH Nair, SP Narayanan - Drug discovery today, 2023 - Elsevier
Highlights•According to in-vitro and in-silico investigations, the phytochemicals discussed in
this review show anti-amyloid potential.•Some phytochemicals have blood brain barrier …

[HTML][HTML] Antisense therapy: a potential breakthrough in the treatment of neurodegenerative diseases

R Romano, C Bucci - Neural Regeneration Research, 2024 - journals.lww.com
Neurodegenerative diseases are a group of disorders characterized by the progressive
degeneration of neurons in the central or peripheral nervous system. Currently, there is no …

[HTML][HTML] Harnessing the potential of mesenchymal stem cells–derived exosomes in degenerative diseases

HJ Liao, YP Yang, YH Liu, HC Tseng, TI Huo… - Regenerative …, 2024 - Elsevier
Mesenchymal stem cells (MSCs) have gained attention as a promising therapeutic approach
in both preclinical and clinical osteoarthritis (OA) settings. Various joint cell types, such as …

Mannich reaction mediated derivatization of chromones and their biological evaluations as putative multipotent ligands for the treatment of Alzheimer's disease

N Kumar, K Jangid, V Kumar, B Devi, T Arora… - RSC Medicinal …, 2024 - pubs.rsc.org
Alzheimer's disease (AD) is a complex neurological disorder and multiple pathways are
associated with its pathology. Currently available single-targeting drugs are found to be …

Synergistic neuroprotection by phytocompounds of Bacopa monnieri in scopolamine-induced Alzheimer's disease mice model

S Shoukat, MA Zia, M Uzair, RA Alsubki, K Sajid… - Molecular biology …, 2023 - Springer
Background Millions of people around the globe are affected by Alzheimer's disease (AD).
This crippling condition has no treatment despite intensive studies. Some phytocompounds …