Protein misfolding and aggregation are characteristic of a wide range of neurodegenerative
disorders, including Alzheimer and Parkinson diseases. A hallmark of these diseases is the …

This report covers advances in capillary electrophoresis (CE) from January 2018 through
September 2019. A summary of the literature during this time period is insightful. A search …

Liquid–liquid phase separation underlies the formation of biological condensates.
Physically, such systems are microemulsions that in general have a propensity to fuse and …

DNA circuits form the basis of programmable molecular systems capable of signal
transduction and algorithmic computation. Some classes of molecular programs, such as …

Exploration and characterisation of the human proteome is a key objective enabling a
heightened understanding of biological function, malfunction and pharmaceutical design …

Oligomers comprised of misfolded proteins are implicated as neurotoxins in the
pathogenesis of protein misfolding conditions such as Parkinson's and Alzheimer's …

Nucleic acid aptamers show clear promise as diagnostic reagents, as highly specific strands
were reported against a large variety of biomarkers. They have appealing benefits in terms …

Membraneless organelles formed through condensation of biomolecules in living cells have
become the focus of sustained efforts to elucidate their mechanisms of formation and …

Shear forces affect self-assembly processes ranging from crystallization to fiber formation.
Here, the effect of mild agitation on amyloid fibril formation was explored for four peptides …

The detection of proteins is of central importance to biomolecular analysis and diagnostics.
Typical immunosensing assays rely on surface-capture of target molecules, but this …