Quantifying misfolded protein oligomers as drug targets and biomarkers in Alzheimer and Parkinson diseases
K Kulenkampff, AM Wolf Perez, P Sormanni… - Nature Reviews …, 2021 - nature.com
Protein misfolding and aggregation are characteristic of a wide range of neurodegenerative
disorders, including Alzheimer and Parkinson diseases. A hallmark of these diseases is the …
disorders, including Alzheimer and Parkinson diseases. A hallmark of these diseases is the …
Challenging bioanalyses with capillary electrophoresis
This report covers advances in capillary electrophoresis (CE) from January 2018 through
September 2019. A summary of the literature during this time period is insightful. A search …
September 2019. A summary of the literature during this time period is insightful. A search …
Surface electrostatics govern the emulsion stability of biomolecular condensates
Liquid–liquid phase separation underlies the formation of biological condensates.
Physically, such systems are microemulsions that in general have a propensity to fuse and …
Physically, such systems are microemulsions that in general have a propensity to fuse and …
Digital sensing and molecular computation by an enzyme-free DNA circuit
DNA circuits form the basis of programmable molecular systems capable of signal
transduction and algorithmic computation. Some classes of molecular programs, such as …
transduction and algorithmic computation. Some classes of molecular programs, such as …
Microfluidic approaches for the analysis of protein–protein interactions in solution
Exploration and characterisation of the human proteome is a key objective enabling a
heightened understanding of biological function, malfunction and pharmaceutical design …
heightened understanding of biological function, malfunction and pharmaceutical design …
Rapid structural, kinetic, and immunochemical analysis of alpha-synuclein oligomers in solution
Oligomers comprised of misfolded proteins are implicated as neurotoxins in the
pathogenesis of protein misfolding conditions such as Parkinson's and Alzheimer's …
pathogenesis of protein misfolding conditions such as Parkinson's and Alzheimer's …
Aptamers against immunoglobulins: Design, selection and bioanalytical applications
Z Bognár, RE Gyurcsányi - International Journal of Molecular Sciences, 2020 - mdpi.com
Nucleic acid aptamers show clear promise as diagnostic reagents, as highly specific strands
were reported against a large variety of biomarkers. They have appealing benefits in terms …
were reported against a large variety of biomarkers. They have appealing benefits in terms …
Microfluidics for multiscale studies of biomolecular condensates
Membraneless organelles formed through condensation of biomolecules in living cells have
become the focus of sustained efforts to elucidate their mechanisms of formation and …
become the focus of sustained efforts to elucidate their mechanisms of formation and …
The role of shear forces in primary and secondary nucleation of amyloid fibrils
Shear forces affect self-assembly processes ranging from crystallization to fiber formation.
Here, the effect of mild agitation on amyloid fibril formation was explored for four peptides …
Here, the effect of mild agitation on amyloid fibril formation was explored for four peptides …
Direct digital sensing of protein biomarkers in solution
The detection of proteins is of central importance to biomolecular analysis and diagnostics.
Typical immunosensing assays rely on surface-capture of target molecules, but this …
Typical immunosensing assays rely on surface-capture of target molecules, but this …