Targeting mitosis in cancer: emerging strategies
The cell cycle is an evolutionarily conserved process necessary for mammalian cell growth
and development. Because cell-cycle aberrations are a hallmark of cancer, this process has …
and development. Because cell-cycle aberrations are a hallmark of cancer, this process has …
The spindle-assembly checkpoint in space and time
A Musacchio, ED Salmon - Nature reviews Molecular cell biology, 2007 - nature.com
In eukaryotes, the spindle-assembly checkpoint (SAC) is a ubiquitous safety device that
ensures the fidelity of chromosome segregation in mitosis. The SAC prevents chromosome …
ensures the fidelity of chromosome segregation in mitosis. The SAC prevents chromosome …
NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1
X Zhang, X Huang, J Xu, E Li, M Lao, T Tang… - Nature …, 2021 - nature.com
Despite the substantial impact of post-translational modifications on programmed cell death
1 ligand 1 (PD-L1), its importance in therapeutic resistance in pancreatic cancer remains …
1 ligand 1 (PD-L1), its importance in therapeutic resistance in pancreatic cancer remains …
Cell cycle regulation by the NEK family of protein kinases
Genetic screens for cell division cycle mutants in the filamentous fungus Aspergillus
nidulans led to the discovery of never-in-mitosis A (NIMA), a serine/threonine kinase that is …
nidulans led to the discovery of never-in-mitosis A (NIMA), a serine/threonine kinase that is …
Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival
MT Landi, T Dracheva, M Rotunno, JD Figueroa, H Liu… - PloS one, 2008 - journals.plos.org
Background Tobacco smoking is responsible for over 90% of lung cancer cases, and yet the
precise molecular alterations induced by smoking in lung that develop into cancer and …
precise molecular alterations induced by smoking in lung that develop into cancer and …
Cdc20: a WD40 activator for a cell cycle degradation machine
H Yu - Molecular cell, 2007 - cell.com
Cdc20 is an essential cell-cycle regulator required for the completion of mitosis in organisms
from yeast to man and contains at its C terminus a WD40 repeat domain that mediates …
from yeast to man and contains at its C terminus a WD40 repeat domain that mediates …
Targeting NEK2 as a promising therapeutic approach for cancer treatment
Y Fang, X Zhang - Cell Cycle, 2016 - Taylor & Francis
ABSTRACT Never in Mitosis (NIMA) Related Kinase 2 (NEK2) plays a key role in regulating
mitotic processes, including centrosome duplication and separation, microtubule …
mitotic processes, including centrosome duplication and separation, microtubule …
Mitotic regulation by NIMA-related kinases
The NIMA-related kinases represent a family of serine/threonine kinases implicated in cell
cycle control. The founding member of this family, the NIMA kinase of Aspergillus nidulans …
cycle control. The founding member of this family, the NIMA kinase of Aspergillus nidulans …
PPSP: prediction of PK-specific phosphorylation site with Bayesian decision theory
Background As a reversible and dynamic post-translational modification (PTM) of proteins,
phosphorylation plays essential regulatory roles in a broad spectrum of the biological …
phosphorylation plays essential regulatory roles in a broad spectrum of the biological …
The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer
Aneuploidy and chromosome instability are common abnormalities in human cancer. Loss
of control over mitotic progression, multipolar spindle formation, and cytokinesis defects are …
of control over mitotic progression, multipolar spindle formation, and cytokinesis defects are …