Inhibitory checkpoint blockade therapy is an immunomodulatory strategy that results in the
restoration of T cell functions, and its efficacy depends on the recognition of tumor cells for …

Background Bladder cancer is a common disease worldwide with most patients presenting
with the non-muscle-invasive form (NMIBC) at initial diagnosis. Postoperational intravesical …

Optical molecular imaging holds the potential to improve cancer diagnosis. Fluorescent
nanoparticles such as quantum dots (QD) offer superior optical characteristics compared to …

A synthetic lethality–based strategy has been developed to identify therapeutic targets in
cancer harboring tumor-suppressor gene mutations, as exemplified by the effectiveness of …

Purpose: Prolyl 3-hydroxylase family member 4 (P3H4) is a potent prognostic oncogene in
bladder cancer (BC), and the inhibition of P3H4 suppresses BC tumor growth. This study …

Gene therapy has garnered significant attention as a therapeutic approach for bladder
cancer but efficient delivery and gene expression remain major hurdles. The goal of this …

The characterization of murine cell lines is of great importance in order to identify preclinical
models that could resemble human diseases. Aberrant glycosylation includes the loss …

This protocol describes the generation of bladder tumors in female C57BL/6J mice using the
murine bladder cancer cell line MB49, which has been modified to secrete human Prostate …

The standard treatment of nonmuscle invasive bladder cancer (NMIBC) is transurethral
resection of the tumors, followed by intravesical therapy (IT), which comprises a direct …

Urothelial bladder cancer is the most common malignancy of the urinary tract resulting in
over 165,000 deaths worldwide. Immunotherapies targeting the programmed cell death …