[HTML][HTML] APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis

J Wu, Z Ma, A Raman, P Beckerman, P Dhillon… - Immunity, 2021 - cell.com
The incidence and severity of sepsis is higher among individuals of African versus European
ancestry. We found that genetic risk variants (RVs) in the trypanolytic factor apolipoprotein …

Management of traditional risk factors for the development and progression of chronic kidney disease

R Lo, Y Narasaki, S Lei, CM Rhee - Clinical Kidney Journal, 2023 - academic.oup.com
Chronic kidney disease (CKD) and its downstream complications (ie cardiovascular) are a
major source of morbidity worldwide. Additionally, deaths due to CKD or CKD-attributable …

Cardiovascular disease: an introduction

M Thiriet, M Thiriet - Vasculopathies: Behavioral, Chemical, Environmental …, 2018 - Springer
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[HTML][HTML] Antisense oligonucleotides ameliorate kidney dysfunction in podocyte-specific APOL1 risk variant mice

YW Yang, B Poudel, J Frederick, P Dhillon, R Shrestha… - Molecular Therapy, 2022 - cell.com
Coding variants (named G1 and G2) in Apolipoprotein L1 (APOL1) can explain most excess
risk of kidney disease observed in African American individuals. It has been proposed that …

Niacin increases atherogenic proteins in high-density lipoprotein of statin-treated subjects

GE Ronsein, T Vaisar, WS Davidson… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Niacin therapy fails to reduce cardiovascular events in statin-treated subjects
even though it increases plasma HDL-C (HDL [high-density lipoprotein] cholesterol) and …

[HTML][HTML] C1QL1/CTRP14 is largely dispensable for atherosclerosis formation in apolipoprotein-E-deficient mice

H Guan, T Shi, M Liu, X Wang, F Guo - Journal of Cardiovascular …, 2022 - mdpi.com
The purpose of this study was to investigate the influence of C1QL1 on atherosclerosis as
well as the transcriptomic alteration of the aorta. While complement C1ql-like 1 (C1QL1) is …

[HTML][HTML] Assessing known chronic kidney disease associated genetic variants in Saudi Arabian populations

C Cyrus, S Al-Mueilo, C Vatte, S Chathoth, YR Li… - BMC nephrology, 2018 - Springer
Background Genome wide association studies of patients with European descent have
identified common variants associated with risk of reduced estimated glomerular filtration …

Recent Highlights of ATVB Lipoproteins

JS Dron, J Lazarte, RA Hegele - Arteriosclerosis, Thrombosis, and …, 2018 - Am Heart Assoc
ABCA1 is central to reverse cholesterol transport; its transcription is regulated by LXRs (liver
X receptors) in response to intracellular cholesterol. 26 Nelson et al27 analyzed the …

Improving Knowledge and Perception of Cardiovascular Disease Amongst African Americans

TR Curry - 2020 - search.proquest.com
The purpose of this project was to evaluate and improve knowledge and perceptions
ofcardiovascular disease through culturally sensitive education. African Americans remain …