Directed cell migration is a physical process that requires dramatic changes in cell shape
and adhesion to the extracellular matrix. For efficient movement, these processes must be …

▪ Abstract Nerve regeneration is a complex biological phenomenon. In the peripheral
nervous system, nerves can regenerate on their own if injuries are small. Larger injuries …

The central component in the road trip of axon guidance is the growth cone, a dynamic
structure that is located at the tip of the growing axon. During its journey, the growth cone …

Axon outgrowth and guidance to the proper target requires the coordination of filamentous
(F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape …

To migrate, a cell first extends protrusions such as lamellipodia and filopodia, forms
adhesions, and finally retracts its tail. The actin cytoskeleton plays a major role in this …

▪ Abstract The conversion of physical signals, such as contractile forces or external
mechanical perturbations, into chemical signaling events is a fundamental cellular process …

Recent studies indicate the actin and microtubule cytoskeletons are a final common target of
many signaling cascades that influence the developing neuron. Regulation of polymer …

Unlike other tissue types, like epithelial tissue, which consist of cells with a much more
homogeneous structure and function, the nervous tissue spans in a complex multilayer …

Netrins are secreted proteins that were first identified as guidance cues, directing cell and
axon migration during neural development. Subsequent findings have demonstrated that …

Cell movement is a complex phenomenon primarily driven by the actin network beneath the
cell membrane, and can be divided into three general components: protrusion of the leading …