As a nontraditional T-cell subgroup, γδT cells have gained popularity in the field of
immunotherapy in recent years. They have extraordinary antitumor potential and prospects …

Epithelial surfaces line the body and provide a crucial interface between the body and the
external environment. Tissue-resident epithelial γδ T cells represent a major T cell …

INTRODUCTION T cells represent a key component of the immune system that can
recognize foreign molecules (antigens) via cognate cell surface receptors termed T cell …

Human leukocyte antigen (HLA)-independent, T cell–mediated targeting of cancer cells
would allow immune destruction of malignancies in all individuals. Here, we use genome …

While most studies of T lymphocytes have focused on T cells reactive to complexes of
peptide and major histocompatibility complex (MHC) proteins, many other types of T cells do …

In both cancer and infections, diseased cells are presented to human Vγ9Vδ2 T cells
through an 'inside out'signalling process whereby structurally diverse phosphoantigen (pAg) …

With the promise of T cell-based therapy for cancer finally becoming reality, this Review
focuses on the less-studied γδ T cell lineage and its diverse responses to tumours. γδ T cells …

Summary Vγ9Vδ2 T cells respond in a TCR-dependent fashion to both microbial and host-
derived pyrophosphate compounds (phosphoantigens, or P-Ag). Butyrophilin-3A1 …

Mycobacterium tuberculosis is a leading cause of mortality worldwide and establishes a
long-lived latent infection in a substantial proportion of the human population. Multiple lines …

Many body surfaces harbor organ-specific γδ T cell compartments that contribute to tissue
integrity. Thus, murine dendritic epidermal T cells (DETCs) uniquely expressing T cell …